Mouse Genome Informatics (MGI) is a free, online database andbioinformatics resource hosted byThe Jackson Laboratory, with funding by theNational Human Genome Research Institute (NHGRI), theNational Cancer Institute (NCI), and theEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).[1] MGI provides access to data on the genetics, genomics and biology of the laboratory mouse to facilitate the study of human health and disease.[2][3] The database integrates multiple projects, includingMouse Models of Human Cancer database, Mouse Genome Database, and Mouse Gene Expression Database (GXD).[4] As of 2018[update], MGI contains data curated from over 230,000 publications.[5]
The MGI resource was first published online in 1994[5] and is a collection of data, tools, and analyses created and tailored for use in thelaboratory mouse, a widely usedmodel organism. It is "the authoritative source of official names for mouse genes, alleles, and strains", which follow the guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice.[6] The history and focus of Jackson Laboratory research and production facilities generates tremendous knowledge and depth which researchers can mine to advance their research. A dedicated community of mouse researchers, worldwide enhances and contributes to the knowledge as well. This is an indispensable tool for any researcher using the mouse as a model organism for their research, and for researchers interested in genes that share homology with the mouse genes. Various mouse research support resources including animal collections and free colony management software are also available at the MGI site.[7]
TheMouse Genome Database collects and curates comprehensive phenotype and functional annotations formousegenes andalleles.[8] This is anNHGRI-funded project which contributes to the Mouse Genome Informatics database.
TheGene Expression Database is a community resource of mouse developmental expression information.[9]
MGI evolved from a project funded by theNational Center for Human Genome Research in 1989 to combine the databases of several Jackson Laboratory scientists and create a tool for visualizing data on the mouse genome.[10] The result of that project, led by Joseph H. Nadeau, Larry E. Mobraaten, and Janan T. Eppig, was called the "Encyclopedia of the Mouse Genome" and distributed viafloppy disk semi-annually to around 300 scientists around the world.[10] In 1992, that group joined with the team responsible for developing the "Genomic Database for Mouse", led by Muriel T. Davisson and Thomas H. Roderick, to start the "Mouse Genome Informatics" project.[10] That project resulted in the first online release of the "Mouse Genome Database" in 1994.[10]
