Morgagni–Stewart–Morel syndrome | |
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Other names | Hyperostosis frontalis interna,' Metabolic craniopathy |
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Morgagni–Stewart–Morel syndrome is inherited in an X-linked recessive manner (or autosomal dominant).[1] | |
Specialty | Endocrinology |
Morgagni–Stewart–Morel syndrome is a condition with a wide range of associatedendocrine problems including:diabetes mellitus,diabetes insipidus, andhyperparathyroidism.[2] Other signs and symptoms includeheadaches,vertigo,hirsutism,menstrual disorder,galactorrhoea,obesity,depression, andseizures.[2] It is characterized by a thickening of the inner table of the frontal part of the skull, a usually benign condition known ashyperostosis frontalis interna.[2][3] The syndrome was first described in 1765.[3] It is named after the Italian anatomist and pathologistGiovanni Battista Morgagni, the British neurologistRoy Mackenzie Stewart, and the Swiss psychiatristFerdinand Morel.
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The diagnosis of Morgagni–Stewart–Morel is based upon a radiological finding ofhyperostosis frontalis interna. Diagnosis considers a combination of clinical features including obesity,[4]virilism, and mental disturbances.[5]
Treatment is based upon the symptoms, and generally includes medication, diet and lifestyle modification for weight control. Seizures and headaches associated with hyperostosis frontalis interna (HFI) are treated with standard medications.[6]
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