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| Names | |
|---|---|
| Preferred IUPAC name N-(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)-4-[4-(4-fluorophenyl)piperazin-1-yl]butanamide | |
| Identifiers | |
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| Properties | |
| C28H30FN3OS | |
| Molar mass | 475.63 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Monatepil is acalcium channel blocker andα1-adrenergic receptorantagonist used as anantihypertensive.[1]
The synthesis of monatepil was first disclosed in patents filed by Dainippon Pharmaceutical.[2]
The amino group of the dihydrodibenzothiepin (1) is first reacted with theacid chloride of 4-chlorobutyric acid, to give theamide (3). This is then used toalkylatepara-fluorophenylpiperazine (4) to yield monatepil.[2][3]
 | Thisdrug article relating to thecardiovascular system is astub. You can help Wikipedia byexpanding it. |
