Moclobemide, sold under the brand namesAmira,Aurorix,[8]Clobemix,Depnil andManerix[9] among others, is areversible inhibitor of monoamine oxidase A (RIMA) drug primarily used to treatdepression andsocial anxiety.[10][11][12] It is not approved for use in the United States,[13] but is approved in other Western countries such as Canada, the United Kingdom[12] and Australia.[14] It is produced by affiliates of theHoffmann–La Roche pharmaceutical company. Initially, Aurorix was also marketed by Roche in South Africa, but was withdrawn after its patent rights expired andCipla Medpro's Depnil and Pharma Dynamic's Clorix became available at half the cost.
No significant rise in blood pressure occurs when moclobemide is combined with amines such astyramine-containing foods or pressor amine drugs, unlike with the older irreversible and non-selectivemonoamine oxidase inhibitors (MAOIs), which cause a severe rise in blood pressure with such combination.[10] Due to the lack ofanticholinergic,cardiovascular, cognitive and psychomotor impairments moclobemide is advantageous in the elderly as well as those with cardiovascular disease.[10]
Moclobemide was first introduced for medical use in 1989.[15][16]
Reversible selective MAOIs such as moclobemide are underprescribed due to the misconception that the side effect profiles are analogous to that of the irreversible and non-selective MAOIs.[17] MAOIs such as moclobemide are reported to have a relatively fast onset of action compared to other antidepressant drug classes,[18] and have good long-term tolerability in terms of side effects.[19]
Tolerance does not seem to occur; research has found that moclobemide retains its beneficial therapeutic properties in depression for at least a year.[20]
Unipolar depression – Moclobemide has demonstrated effectiveness and efficacy in the treatment and management ofmajor depressive disorder,[21] with both endogenous and non-endogenous depression responding; in addition moclobemide has a fast onset of action compared to other antidepressants and is significantly more tolerable than the tricyclic antidepressants.[22] Due to a good safety profile and low incidence of side effects moclobemide is likely to have a high level of acceptability by individuals suffering from depression.[23] Higher doses (>450 mg/day) may be more effective in severe depression, while patients treated with a lower dose tend to respond less well than those treated withtricyclic antidepressants.[24]
Psychotic depression, unipolarendogenous depression,melancholic depression,retarded depression,agitated depression andneurotic depression all respond to moclobemide,[25] as doesatypical depression.[26] Unipolarendogenous depression is reported to have the best response to moclobemide therapy.[27][28] Individuals suffering from depression who are given moclobemide are twice as likely to improve on moclobemide than onplacebo.[29] A concern of antidepressant adverse effects is sexual dysfunction; however, moclobemide has been found to actually increase libido and improve impaired erection, ejaculation and orgasm.[30] Cardiovascular toxicity is a concern with antidepressants such as tricyclic antidepressants as well as the irreversible MAOIs; when cardiovascular toxicity is a concern, SSRIs or the reversible MAOIs such as moclobemide are an option as they lack or have a significantly reduced level of cardiovascular toxicity in terms of adverse effect as well as in overdose.[31]
The effectiveness of moclobemide in agitated depression is equivalent to that ofimipramine and sedative antidepressants such asamitriptyline,mianserin andmaprotiline. The therapeutic response in agitated depressive individuals is similar to that seen in non-agitated depression; however, a past history of use of antidepressants reduces the chance of successful therapeutic response. The addition of abenzodiazepine to moclobemide therapy has not been found to be of benefit in this population group.[32] Moclobemide has better tolerability compared toTCAs.[33][34]
Dysthymia – moclobemide has been found to be effective in the treatment and management of this depressive disorder.[35]
Social phobia – Moclobemide has been found to be effective for the treatment of social anxiety disorder in both short and long-term placebo controlled clinical trials.[36] Moclobemide is effective but not as effective as the irreversible MAOIs in the treatment of social phobia.[37] Maximal benefits can take 8–12 weeks to manifest.[38] There is a high risk of treatment failure if there is co-morbidalcohol use disorder, however.[39] TheAustralian Medicines Handbook lists social phobia as an accepted but not a licensed indication.[11] The use of moclobemide in the treatment of social anxiety disorder has given mixed results with a tendency of response at higher doses (>300 mg/d) compared with placebo.[40]
Smoking cessation – Moclobemide has been tested in heavy dependent smokers against placebo based on the theory that tobacco smoking could be a form of self-medicating ofmajor depression,[41] and moclobemide could therefore help increase abstinence rates due to moclobemide mimicking the MAO-A inhibiting effects oftobacco smoke. A 2023 Cochrane review[42] found only one 1995 trial[41] studying the effects of moclobemide on smoking cessation, it was administered for 3 months and then stopped; at 6 months follow-up it was found those who had taken moclobemide for 3 months had a much higher successful quit rate than those in the placebo group. However, at 12-month follow-up the difference between the placebo group and the moclobemide group was no longer significant.
Panic disorder – moclobemide is useful in the treatment and management of panic disorder.[43] Panic disorder is mentioned as an accepted but unlicensed indication in the Australian Medicines Handbook.[11]
ADHD – Two small studies assessing the benefit of moclobemide in people with attention deficit disorder found that moclobemide produced favourable results.[25]
Fibromyalgia – moclobemide has been found to improve pain and functioning in this group of people.[44]
Similar to other MAOIs, reversible MAOIs such as moclobemide may also be effective in a range of other psychiatric disorders.[25][45][which?]Menopausal flushing may also respond to moclobemide.[46]
In efficacy studies for the treatment of major depressive disorder, moclobemide has been found to be significantly more effective than placebo, as effective as the tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), and somewhat less effective than the older, irreversible MAOIsphenelzine andtranylcypromine. In terms of tolerability, however, moclobemide was found to be comparable to the SSRIs and better tolerated than the TCAs and older MAOIs.[13] There is some evidence that moclobemide on its own or in combination with other antidepressants such as SSRIs is also effective fortreatment resistant depression and that the combination can be administered without the development of serotonin syndrome; however, further research is needed before such a combination can be recommended.[10][47] Follow-up studies show that ongoing use of antidepressants leads to continuing improvement in depression over time; and also have demonstrated that moclobemide retains its therapeutic efficacy as an antidepressant for at least a year. This long-term efficacy is equivalent to that seen with other antidepressant classes.[17]
People on irreversible MAOIs have to discontinue these antidepressants two weeks before general anesthesia, however, the use of moclobemide, due to its reversible nature, would allow such patients to possibly continue antidepressant therapy.[48][49]
The doses of moclobemide in breast milk are very low (0.06% of moclobemide being recovered in breast milk) and therefore it has been concluded that moclobemide is unlikely to have any adverse effect on a suckling baby.[9]
Reversible MAOIs such as moclobemide may have advantages in the treatment of depression associated withAlzheimer's disease due to its effect on noradrenaline.[55] Cognitive impairments have been found to improve in people with dementia when depression is treated with moclobemide.[25] Due to its superior safety profile, moclobemide has been recommended as a first line agent for the treatment of depression in the elderly.[56] Due to the side effect profile of moclobemide, it may be a better option for this sub group of people than other antidepressants.[57] Research has found evidence that moclobemide may be able to counter anti-cholinergic (Scopolamine) induced cognitive impairments thus making moclobemide a good choice in the depression in the elderly and those with dementia.[58]
The incidence of adverse events is not correlated with age; however, adverse events occur more often in females than in males.[59] Moclobemide is regarded as a generally safe antidepressant and due to its favorable side effect profile, it can be considered a first-line therapeutic antidepressant.[60] The rate of incidence of side effects of moclobemide is low,[23] withinsomnia, headache and dizziness being the most commonly reported side effects in the initial stages of therapy with moclobemide.[61] Moclobemide, even at high doses of 600 mg, does not impair the ability to drive a motor vehicle.[9][2] The tolerability of moclobemide is similar in women and men and it is also well tolerated in the elderly.[62] Moclobemide has been found to be superior totricyclic and irreversible MAOI antidepressants in terms of side effects, as it does not causeanticholinergic, sedative or cardiovascular adverse effects.[10][2]
Unlike the irreversible MAOIs there is no evidence of liver toxicity with moclobemide.[63] Moclobemide has a similar efficacy profile compared to other antidepressants while being superior to the classic MAOIs and the tricyclics in terms of tolerance and safety profile.[64] Moclobemide has little effect onpsychomotor functions.[65] Other side effects include nausea, insomnia, tremor and lightheadedness;orthostatic hypotension (dizziness upon standing) is uncommon even among the elderly.[13] Behavioural toxicity or other impairments relating to everyday living does not occur with moclobemide, except that in doses of 400 mg or higher peripheral reaction time may be impaired.[66]Peripheral oedema has been associated with moclobemide.[67]
Some of the side effects are transient and disappear within 2 weeks of treatment.[68]Serious fatigue, headache, restlessness, nervousness and sleep disturbances have been described as side effects from moclobemide therapy.[69] Aparadoxical worsening of depression has been reported in some individuals in several studies,[70] and reports of suicide or suicidal ideation have been reported as a rare adverse effect of moclobemide.[71] Overall, antidepressants decrease the risk of suicide.[72] Moclobemide is believed to have only small proconvulsant effects;[73] however, rarely seizures may occur.[74]Hypertension has been reported to occur very rarely with moclobemide therapy.[13]
Moclobemide is relatively well tolerated. The following are the potential adverse effects and their respective incidences:[14][75]
Withdrawal symptoms appear to be very rare with moclobemide compared to other antidepressants[citation needed]; a single report of relatively mild flu-like symptoms persisting for 7 days after rapid reduction of high dose moclobemide therapy has been reported in one patient.[76] Withdrawal of moclobemide causes a rebound in REM sleep.[9]
Discontinuation of moclobemide is recommended to be done gradually to minimise side effects (e.g. rapid return of condition being treated and/or the appearance of withdrawal symptoms). Tolerance to the therapeutic effects has been reported in a small number of users of MAOIs including moclobemide.[17]
Moclobemide is considered to be less toxic in overdose compared to older antidepressants, such as the tricyclic antidepressants and the irreversible and non-selective MAOIs,[10] making it a safer antidepressant in the elderly or people with physical disorders.[2] Of 18 people who overdosed on moclobemide during clinical trials, all recovered fully and moclobemide was judged to be safe for inpatient as well as outpatient use.[78] Intoxications with moclobemide as single agent are usually mild; however, when combined with tricyclic or SSRI antidepressants the overdose is much more toxic and potentially fatal.[79][80] Moclobemide, is preferred by doctors for patients who are at risk of suicide, due to moclobemide's low toxicity in overdose.[81] Patients with mixed intoxications (e.g. with other CNS active drugs) may show severe or life-threatening symptoms and should be hospitalized. Treatment is largely symptomatic and should be aimed at maintenance of the vital functions.
Acute toxicity: The oralLD50 values in mouse and rat are quite high, indicating a widetherapeutic index. LD50 for mice is 730 mg/kg and for rats 1,300 mg/kg. In dogs doses in excess of 300 mg/kg led tovomiting,salivation,ataxia, anddrowsiness.
Chronic toxicity: In an 18-months-study in rats with 10 mg/kg no signs of chronic toxicity were noted, with 50 mg/kg and 250 mg/kg only a slight loss of weight, and with 250 mg/kg mildly elevatedAlkaline phosphatase andGamma-GT. Studies in dogs revealed no toxicity relevant for humans. No evidence for a possiblehepatic orcardiovascular toxicity was found.
Moclobemide has fewer interactions than irreversible MAOIs.Cimetidine however, causes a significant rise in moclobemide levels and therefore if the combination is used, lower doses of moclobemide have been recommended.[82] There is little increase in the effects ofalcohol when combined with moclobemide[82] and, in fact, moclobemide causes a reduction in alcohol-related impairments.[65] Moclobemide also interacts withpethidine/meperidine,[83] anddextropropoxyphene.[64]Ephedrine in combination with moclobemide increases the risk of cardiovascular adverse effects.[84] Moclobemide is also likely to interact withwarfarin.[85]The combination of moclobemide with prescription or over the countersympathomimetic drugs is not recommended due to the potential of significant drug interactions.[86]
Serotonin syndrome has been reported when moclobemide has been taken in combination with other serotonin enhancing drugs; however, due to moclobemide's reversible MAO inhibition, serotonin syndrome is significantly less likely to occur with moclobemide than with older irreversible MAOIs.[11][87][88]Serotonin syndrome has been reported whentrazodone was abruptly replaced with moclobemide.[89] Taking at the same time or starting moclobemide too soon after discontinuingclomipramine or serotonin reuptake inhibitors such as SSRIs may result in the development of a serotonin syndrome.[64][90]SNRIs such as venlafaxine in combination with moclobemide have also been associated with serotonin syndrome.[91]Cimetidine causes a doubling of the blood plasma levels of moclobemide.[9] Blood plasma levels oftrimipramine andmaprotiline and possibly other tricyclic antidepressants increase when used in combination with moclobemide and may require dosage adjustments if the combination is used for treatment resistant depression.[92] The elimination ofzolmitriptan is reduced by moclobemide and if the combination is used, a dose reduction of zolmitriptan is recommended.[93] Moclobemide reduces the metabolism ofdextromethorphan.[94] Moclobemide may decrease metabolism of diazepam, omeprazole, proguanil, propranolol and others due to inhibition of CYP2C19.[95]
Irreversible MAOIs can cause unpleasant and occasionally dangerous side effects such as ahypertensive crises after intake of food or drink containing indirectly acting sympathomimetic amines such astyramine. This is sometimes referred to as the 'cheese effect'. These side effects are due to irreversible inhibition of MAO in the gut and vasomotor neurons. However, the reversible MAOI antidepressants such as moclobemide have a very different side effect profile in this regard.[9] The reversible binding to MAO-A by moclobemide allows amines such as tyramine to displace moclobemide from MAO-A allowing its metabolism and removing the risk of a hypertensive crisis that occurs with irreversible MAO inhibition.[96] Of 2300 people in multiple clinical trials who were treated with moclobemide in doses up to 600 mg with no dietary restrictions, none experienced a tyramine-mediatedhypertensive reaction.[62] As the pressor effect of moclobemide is so low, dietary restrictions are not necessary in people eating a normal diet, in contrast to irreversible MAOIs.[10] However, some rare cheeses that have a high tyramine level may possibly cause a pressor effect and require caution.[97] The potentiation of the pressor effect of tyramine by moclobemide is only one seventh to one tenth of that of irreversible MAOIs.[98] In order to minimize this potentiation, postprandial administration (taken after meals) of moclobemide is recommended.[9] The combined use of moclobemide andselegiline requires dietary restrictions as the combination can lead to increased sensitivity to the pressor effect of foods containing tyramine.[99]
While moclobemide or the irreversible MAO-B selective inhibitor selegiline taken alone has very little pressor effect, and requires no dietary restriction, the combination ofselegiline with moclobemide leads to a significant enhancement of the pressor effect and such a combination requires dietary restriction of foods containing high amounts oftyramine.[100] The combination of moclobemide and a reversible MAO-B inhibitor requires tyramine dietary restrictions.[101]
A picture of 150 mg tablets of the reversibleMAOI drug moclobemide, brand name Aurorix.
Moclobemide is abenzamide,[13] derivative ofmorpholine,[102] which acts pharmacologically as a selective,reversible inhibitor of monoamine oxidase-A (RIMA),[10] a type of monoamine oxidase inhibitor (MAOI), and increases levels ofnorepinephrine (noradrenaline),dopamine, and especiallyserotonin[9][103] in neuronal cells as well as insynaptic vesicles;extracellular levels also increase which results in increasedmonoamine receptor stimulation and suppression ofREM sleep, down regulation ofbeta-3 adrenergic receptors. Moclobemide's primary action is to disable MAO-A enzymes from decomposing norepinephrine, serotonin, and dopamine which results in a rising level of these neurotransmitters. Although it has been estimated that a single 300 mg dose of moclobemide inhibits 80% of monoamine oxidase-A (MAO-A) and 20-30% of MAO-B,[104] studies evaluating brain occupancy of MAO-A enzymes have shown dosages of 600 mg to only inhibit 74% of MAO-A enzymes[105] and dosages in the 900–1200 mg range to inhibit slightly less MAO-A thanphenelzine (Nardil) at 45–60 mg;[106] subsequently, it is highly plausible that reports of lower efficacy[107] could be largely or entirely the consequence of conservative dosage guidelines rather than the pharmacological properties of the drug. Previously, it was widely reported that both MAO-A and MAO-B enzymes were responsible for the metabolism of dopamine; however, new research suggests that MAO-B enzymes are involved in the generation of GABA and not the degradation of dopamine.[108] There is also some evidence of moclobemide possessingneuroprotective properties in rodent models.[9] There is no cumulative effect of moclobemide centrally when taken long-term.[9] With long-term use of moclobemide, there is a significantdown-regulation ofB-adrenoceptors.[9] Single or repeated dosing with 100–300 mg of moclobemide leads to a reduction in deaminated metabolites ofamines such as3,4-dihydroxyphenylacetic acid,3,4-dihydroxyphenylethylglycol as well as5-HIAA. Excretion ofhomovanillic acid andvanillylmandelic acid via urine is also reduced. There is also a temporary increase inprolactin during initial intake of 100–300 mg of moclobemide.[9] L-dihydroxyphenylalanine is also reduced.[109] Inhibition of the serotonin metabolite is less pronounced than the norepinephrine metabolite which suggests there are other major metabolic pathways for serotonin other than MAO-A.[110]
It has been described as a 'slow binding inhibitor', whereby conformational changes to either moclobemide or the enzyme to MAO-A slowly form a more tightly bound complex, resulting in the non-competitive MAO inhibition by moclobemide.[9] With three times daily dosing the inhibition on MAO-A was relatively constant with moclobemide.[111] The MAO inhibition of moclobemide lasts about 8–10 hours and wears off completely by 24 hours after dosing.[9][103] The inhibition of MAO-A by moclobemide is 10 times more potent than the irreversible MAOI phenelzine and approximately equivalent totranylcypromine andisocarboxazid.[9]
Moclobemide increases levels of extracellularmonoamines and decreases levels of their metabolites in rat brains; tolerance to these effects does not seem to occur with chronic use of moclobemide. Moclobemide lacksanticholinergic effects and cognitive impairments can be improved by moclobemide.[112] Moclobemide suppresses the unstimulated release of certainproinflammatory cytokines which are believed to be involved in the pathophysiology of major depression and stimulates the release of anti-inflammatory cytokines.[113] Long-term treatment with moclobemide leads to an increase incyclic adenosine monophosphate (cAMP) binding tocAMP-dependent protein kinase (PKA).[114]
Moclobemide is chemically unrelated to irreversible MAOI antidepressants and only has a very weak pressor effect of orally administeredtyramine.[115] In humans, the n-oxide metabolites of moclobemide and moclobemide itself are the compounds that produce most of the inhibition of MAO-A; other metabolites are significantly less potent than the parent compound.[9]
In healthy people moclobemide has a relatively small suppressing effect onREM sleep; in contrast, depressed people who have been treated with moclobemide, progressively show improved sleep over a 4-week period, with an increase in stage 2 non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep.[9] There have been conflicting findings with regard to moclobemide alteringcortisol levels and whether moclobemide increasesgrowth hormone levels.[9]Testosterone levels increase significantly with long-term use of moclobemide in depressed males.[116]
Moclobemide also has neuroprotective properties in its demonstrated anti-hypoxia or anti-ischemia effects; there is a possibility that moclobemide may possess similar neuro-rescuing properties, similar toselegiline, however, research is required to determine this.[9] Moclobemide has also been demonstrated in a single dose research study to possessantinociceptive properties.[117]
Platelet MAO is of the MAO-B and this is inhibited only to a small degree in humans; the inhibition is due to low levels of metabolites of moclobemide that have MAO-B inhibiting properties.[118] Moclobemide has been reported to be a mixed MAO-A/MAO-B inhibitor in rats but in man, it has been reported to be a pure MAO-A inhibitor,[119] blocking the decomposition of norepinephrine, serotonin and, to a lesser extent, dopamine. Noreuptake inhibition of any of theneurotransmitters occurs. The pharmacodynamic action encompasses activation, elevation of mood, and improvement of symptoms likedysphoria, fatigue, and difficulties in concentration. The duration and quality of sleep may be improved. In the treatment of depression the antidepressant effect often becomes evident in the first week of therapy (earlier than typically noted with TCAs/SSRIs).
MAO activity returns completely back to normal after 24 hours of the last dose, which allows for a quick switch to another antidepressant after the 24 hours.[9]
In humans moclobemide is rapidly and almost completely absorbed and totally metabolised via the liver.[120] Peak plasma levels occur 0.3 to 2 hours after oral administration. The bioavailability increases during the first week of therapy from 60% to 80% and more. The elimination half-life is around 2 hours.[9][121] It is moderately bound to plasma proteins, especiallyalbumin.[9] However, the short disposition half-life somewhat increases after repeated dosing; moclobemide has an intermediate elimination half-life forsystemic clearance and an intermediatevolume of distribution.[120] Despite its short half-life the pharmacodynamic action of a single dose persists for approximately 16 hours. The drug is almost completely metabolized in the liver; it is a substrate ofCYP2C19 and an inhibitor ofCYP2C19,CYP2D6 andCYP1A2.[122] Less than 1 percent of the drug is excreted unchanged; 92 percent of the metabolised drug is excreted within the first 12 hours.[7] The main metabolites are the N-oxide Ro 12-5637 formed via morpholine N-oxidation and lactam derivative Ro 12-8095 formed via morpholine C-oxidation;[123][124] active metabolites are found only in trace amounts. The unchanged drug (less than 1%) as well as the metabolites are excreted renally (in urine). The main degradation pathway of moclobemide is oxidation.[125] About 44 percent of the drug is lost due to thefirst pass effect through the liver.[126] Age and renal function do not affect the pharmacokinetics of moclobemide. However, patients with significantly reduced liver function require dose reductions due to the significant slowing of metabolism of moclobemide.[127] Food slows the absorption but does not affect the bioavailability of moclobemide.[9]
Steady state concentrations are established after one week.[120] It has been suggested that changes in dose should not be made with a gap of less than a week.[5] Moclobemide has good penetration across theblood brain barrier with peak plasma levels within the central nervous system occurring 2 hours after administration.[128]
Irreversible MAOI antidepressants were discovered accidentally in the 1950s but their popularity declined as their toxicity especially their dangerous food interactions became apparent and rival tricyclic antidepressants were discovered. Reversible MAOIs were developed in the hope that they would exert efficacy in depressive disorders but with less of the toxicity of the older irreversible compounds; moclobemide's discovery and marketing brought the renewed interest in MAOIs due to an absence of dangeroustyramine food interactions and potent antidepressant effects.[19][129] In 1992 moclobemide was launched onto the world markets.[130] Moclobemide was the first reversible MAO-A inhibitor to be widely marketed.[131] Moclobemide as well as other newer antidepressants such as the SSRIs led to changes in prescribing patterns and broadened the treatment options for the management of depressive disorders.[132]
When moclobemide was discovered in 1972 in Switzerland,[13] it was first hypothesized as being anantilipaemic or antibiotic, but the screenings were negative. The search for its antidepressant qualities, based on anticholinergic tests, also proved negative and moclobemide was then suspected of being an antipsychotic before its specific and reversible MAO-A inhibition qualities were detected. After the establishment of its lack of relevant interference with tyramine pressure response, clinical trials were launched in 1977 and further trials confirmed the broad antidepressant activity of RIMAs.[133] It was first approved inSweden in 1989[15][16] and then the United Kingdom and Europe as the first reversible and selective inhibitor of MAO-A and is now approved in over 50countries worldwide.[13] The AustralianTGA approved moclobemide in December 2000.[14] Subsequent research found that moclobemide is well tolerated in elderly patients[34] and far superior to tricyclic antidepressants in terms of side effects, tolerability and overdose. With regard to effectiveness in the treatment of depression, moclobemide was determined to be as effective as all major antidepressant drug classes. There is no need for dietary restrictions in contrast to people on irreversible MAOIs and apart from an important interaction with other serotonergic enhancing agents such as SSRIs and pethidine, there are few serious drug interactions and because of these benefits, moclobemide became regarded as a beneficial addition to medical 'prescribing arsenal'.[88][134] Additionally moclobemide was found, unlike most other antidepressants on the market, to actually improve all aspects of sexual function.[135] It is the only reversible MAOI in use in clinical practice.[9] The fact that moclobemide's pharmacokinetic properties are unaltered by age, that cognition is improved in the elderly, and moclobemide has low potential for food and drug interactions opened up a new avenue for the treatment ofmajor depressive disorder.[9] Due to a lack of financial incentive, such as the costs of conducting the necessary trials to gain approval, moclobemide is unavailable in the US pharmaceutical market.[13] In 2016 moclobemide was discontinued in Brazil for commercial reasons.[136]
It is sold under many trade names worldwide.[137] These include Apo-Moclob, Apo-Moclobemide, Auromid, Aurorix, Bei Su, Biorix, Depnil, Eutac, Hai Bei Lin, Langtian, Manerix, Mobemid, Moclamine, Moclo A, Moclobemid - 1 A Pharma, Moclobemid AL, Moclobemid HEXAL, Moclobemid ratiopharm, Moclobemida, Moclobemida Genedec, Moclobemida Teva, Moclobemide Actavis, Moclobemide Aurobindo, Moclobemide CF, Moclobemide Mylan, Moclobemide Sandoz, Moclobemide Sopharma, Moclobemide Teva, Moclobemid-neuraxpharm, Moclobemid-ratiopharm, Moclobeta, Moclod, moclodura, Moclostad, Mocrim, Moklar, Teva-Moclobemide, Tian Tai, Ya Zheng, and Zorix.[137]
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