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Mitochondrial ribosomal protein L39

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

MRPL39

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3J7Y,3J9M

Identifiers

Aliases

MRPL39, C21orf92, L39mt, MRP-L5, MRPL5, PRED22, PRED66, RPML5, MSTP003, mitochondrial ribosomal protein L39, L5mt

External IDs

OMIM:611845;MGI:1351620;HomoloGene:9679;GeneCards:MRPL39;OMA:MRPL39 - orthologs

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q21.3	Start	25,585,656bp^[1]
Band	21q21.3	End	25,607,517bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C3.3	Start	84,514,464bp^[2]
Band	16\|16 C3.3	End	84,532,630bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

tendon of biceps brachii

left ventricle

right adrenal gland

Achilles tendon

right adrenal cortex

gastrocnemius muscle

secondary oocyte

muscle of thigh

left testis

Top expressed in

fossa

condyle

seminiferous tubule

facial motor nucleus

motor neuron

right ventricle

primitive streak

Paneth cell

medial ganglionic eminence

hair follicle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding RNA binding
Cellular component	mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrial large ribosomal subunit mitochondrion
Biological process	mitochondrial translational elongation mitochondrial translational termination
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


54148


27393

Ensembl


ENSG00000154719


ENSMUSG00000022889

UniProt


Q9NYK5


Q9JKF7

RefSeq (mRNA)


NM_017446 NM_080794


NM_017404 NM_001384093 NM_001384095 NM_001384096

RefSeq (protein)


NP_059142 NP_542984


NP_059100 NP_001371022 NP_001371024 NP_001371025

Location (UCSC)

Chr 21: 25.59 – 25.61 Mb

Chr 16: 84.51 – 84.53 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

39S ribosomal protein L39, mitochondrial is aprotein that in humans is encoded by theMRPL39gene.^[5]^[6]

Mammalianmitochondrial ribosomal proteins are encoded bynuclear genes and help inprotein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%protein torRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition bysequence homology. This gene encodes a 39S subunit protein. Twotranscript variants encoding distinctisoforms have been described. Apseudogene corresponding to this gene is found on chromosome 5q.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000154719 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000022889 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders".Genomics.77 (1–2):65–70.doi:10.1006/geno.2001.6622.PMID 11543634.
^^a ^b"Entrez Gene: MRPL39 mitochondrial ribosomal protein L39".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID 9373149.
O'Brien TW, Fiesler SE, Denslow ND, et al. (2000)."Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences".J. Biol. Chem.274 (51):36043–51.doi:10.1074/jbc.274.51.36043.PMID 10593885.
Spirina O, Bykhovskaya Y, Kajava AV, et al. (2001). "Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing)".Gene.261 (2):229–34.doi:10.1016/S0378-1119(00)00504-7.PMID 11167009.
O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease".Gene.286 (1):73–9.doi:10.1016/S0378-1119(01)00808-3.PMID 11943462.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome".Genomics.81 (5):468–80.doi:10.1016/S0888-7543(03)00004-1.PMID 12706105.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

Protein biosynthesis:translation (bacterial,archaeal,eukaryotic)

Proteins

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Release factor

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X,RPS4Y1,RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Ribosomal RNA /ribosome subunits

Archaea
(70S)

Large (50S):

Small (30S):

Bacteria
(70S)

Large (50S):

Small (30S):

Eukaryotes

Cytoplasmic (80S)	Large (60S): 5S 5.8S 28S Small (40S): 18S
Mitochondrial (55S)	Large (28S): MT-RNR2, 16S MT-tRNA^Val Small (39S): MT-RNR1, 12S
Chloroplast (70S)	Large (50S): 5S 4.5S 23S Small (30S): 16S

Ribosomal proteins

(See article table)

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