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Mitiglinide

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Mitiglinide
Clinical data
Trade namesGlufast
AHFS/Drugs.comInternational Drug Names
Routes of
administration
By mouth (tablets)
ATC code
Identifiers
  • (−)-(2S,3a,7a-cis)-α-Benzylhexahydro-γ-oxo-2-isoindolinebutyric acid
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H25NO3
Molar mass315.413 g·mol−1
3D model (JSmol)
  • O=C(O)[C@@H](Cc1ccccc1)CC(=O)N3C[C@H]2CCCC[C@H]2C3
  • InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23)10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)/t15-,16+,17-/m0/s1 checkY
  • Key:WPGGHFDDFPHPOB-BBWFWOEESA-N checkY
 ☒NcheckY (what is this?)  (verify)

Mitiglinide (INN,[1] trade nameGlufast) is adrug for the treatment oftype 2 diabetes.[2]

Mitiglinide belongs to themeglitinide (glinide) class of blood glucose-lowering drugs and is currently co-marketed in Japan byKissei andTakeda. The North America rights to mitiglinide are held by Elixir Pharmaceuticals. Mitiglinide has not yet gainedFDA approval.

Pharmacology

[edit]

Mitiglinide is thought to stimulateinsulin secretion by closing the ATP-sensitive potassiumKATP channels in pancreaticβ cells.

Dosage

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Mitiglinide is delivered in tablet form.

References

[edit]
  1. ^"International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary names (Rec. INN): List 40"(PDF). World Health Organization. p. 187. Retrieved10 November 2016.
  2. ^Malaisse WJ (October 2008). "Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients".Expert Opinion on Pharmacotherapy.9 (15):2691–8.doi:10.1517/14656566.9.15.2691.PMID 18803455.S2CID 73318104.

External links

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Oraldiabetes medication,insulins andinsulin analogues, and other drugs used in diabetes (A10)
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Combinations
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
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TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
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