| mir-938 | |
|---|---|
| Identifiers | |
| Symbol | mir-938 |
| Rfam | RF00964 |
| miRBase family | MIPF0000469 |
| Other data | |
| RNA type | microRNA |
| Domain | Eukaryota; |
| PDB structures | PDBe |
In molecular biologymir-938 microRNA is a shortRNA molecule.MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-938 has been found to directly target theSMAD3 gene, which encodes the main downstreamTGF-β polypeptideSMAD3. This microRNA is overexpressed in non-functioning pituitary adenomas (NFPAs) compared with normal pituitary tissue.[1] Downregulation of TGF-β signalling is likely to play a role in the regulation of signalling pathways in NFPA tumorigenesis, thus also implicating SMAD3 and miR-938.
