| mir-103/107 microRNA precursor | |
|---|---|
 Predictedsecondary structure andsequence conservation of mir-103 | |
| Identifiers | |
| Symbol | mir-103 |
| Rfam | RF00129 |
| miRBase | MI0000109 |
| miRBase family | MIPF0000024 |
| Other data | |
| RNA type | Gene;miRNA |
| Domain | Eukaryota |
| GO | GO:0035195GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
ThemiR-103 microRNA precursor (homologous to miR-107), is a shortnon-coding RNA gene involved ingene regulation.miR-103 and miR-107 have now been predicted or experimentally confirmed inhuman.[1][2]
microRNAs are transcribed as ~70nucleotide precursors and subsequently processed by theDicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes fromthe 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity tomRNA.[3]
mir-103 and mir-107 were noted as being upregulated inobese mice and were subsequently found to have a key role ininsulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment oftype 2 diabetes.[4]
mir-103 has also been linked withchronic pain[5] andintestinal cell proliferation.[6]
Recently, miR-103-3p was shown to target the 5'untranslated region (5' UTR) ofGPRC5A'smRNA in pancreatic cancer.[7] This is one of only a handful of known instances where amiRNA targets the 5' UTR of a mRNA.