Huddleston started working in comics in the mid-1990s at the age of 21, doing creator-owned projects forSpoon Ink andCaliber, as well as some work forDC Comics, including a short run onDeathstroke withMarv Wolfman up until the title's cancellation. He later called this initial two-year stint a "false start", which prompted him to leave mainstream comics to joinJim Mahfood's 40 Oz Comics studio.[1] Huddleston returned in 2000 with the creator-ownedThe Coffin forOni Press, written byPhil Hester. Since then, Huddleston worked for independent publishers,Marvel and DC Comics, as well as latter'sVertigo andWildstorm imprints, including lengthy runs onHarley Quinn withA. J. Lieberman andGen13 withScott Beatty and creator-owned mini-series such asMnemovore withRay Fawkes andHans Rodionoff andDeep Sleeper, again with Phil Hester.
His latest assignment wasButcher Baker, the Righteous Maker, a creator-owned project at Image withJoe Casey on writing duties.[2][3] The critically acclaimed series ended with issue #8, which was published on August 15, 2012, ten months after issue #7, a delay that Casey stated was due to Huddleston's having overcommitted himself. Huddleston responded to Casey's public statement by stating that the delay was caused by his need to take other work in order to make sufficient money, asButcher Baker was not lucrative enough for him to avoid doing so. Huddleston further explained that he apologized to Casey and to fans for the delay.[4][5]
From 2011 to 2015 Huddleston worked as the artist of the comic adaptation ofGuillermo del Toro'sThe Strain trilogy withDavid Lapham as the writer and del Toro as the consultant.[6][7] Reportedly, del Toro liked Huddleston's approach to design so much that it influenced the way he approached the eventualTV adaptation of the book, as well as the overall development ofThe Strain universe.[8][9]