Miglianico developed as a burgh around the early medievalrocca (Castle), around the 10th century AD.
During the World War II, Miglianico was occupied byGerman forces attempting to hold ground as the American push by General Mark Clark advanced north from Southern Italy. Homes of residents were taken over by German units and used to quarter soldiers and served as command posts. Miglianico and the surrounding area was heavily damaged by Allied carpet bombing during 1944. Many of its residents fled to and lived in caves for months for safety.