| MIR4521 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MIR4521, mir-4521, microRNA 4521 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | GeneCards:MIR4521;OMA:MIR4521 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
MicroRNA 4521 is amicro RNA that in humans is encoded by the MIR4521gene.[3]
microRNAs (miRNAs) are short (20-24nt)non-coding RNAs that are involved inpost-transcriptional regulation ofgene expression inmulticellular organisms by affecting both the stability and translation ofmRNAs. miRNAs are transcribed byRNA polymerase II as part ofcapped andpolyadenylatedprimary transcripts (pri-miRNAs) that can be either protein-coding or non-coding.
The primary transcript is cleaved by theDrosha ribonuclease III enzyme to produce an approximately 70-ntstem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmicDicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into aRNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. TheRefSeq represents the predicted microRNA stem-loop.
miR-4521 has been shown to have decreased expression in various cancers, includingbreast cancer andlung cancer. Ingastric carcinoma, miR-4521 has been reported to inhibitEMT andmetastasis.[4]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
 | This article on agene on humanchromosome 17 is astub. You can help Wikipedia byexpanding it. |
