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| Clinical data | |
|---|---|
| Trade names | Melex, Sedoxil |
| Other names | 13-chloro- 2-(2-chlorophenyl)- 5-methyl- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca- 1(10),11,13-trien- 8-one |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Metabolism | Liver (CYP3A4) |
| Excretion | Kidney |
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| CompTox Dashboard(EPA) | |
| Chemical and physical data | |
| Formula | C18H16Cl2N2O2 |
| Molar mass | 363.24 g·mol−1 |
| 3D model (JSmol) | |
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Mexazolam[1] (marketed under the trade namesMelex andSedoxil)[2] is a drug which is abenzodiazepine derivative.[3] Mexazolam has been trialed for anxiety and was found to be effective in alleviating anxiety at one week follow-up. Mexazolam is metabolised via theCYP3A4 pathway.HMG-CoA reductase inhibitors includingsimvastatin,simvastatin acid,lovastatin,fluvastatin,atorvastatin andcerivastatin inhibit the metabolism of mexazolam,[4] but not the HMG-CoA reductase inhibitorpravastatin.[5][6] Its principal active metabolites are chlorodesmethyldiazepam (also known as chloronordiazepam ordelorazepam, trade name Dadumir) and chloroxazepam (also known aslorazepam, trade name Ativan).[7]
