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Metixene

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From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Metixene
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	N04AA03 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances)^[1]
Identifiers
IUPAC name 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
CAS Number	4969-02-2^Y
PubChemCID	4167
IUPHAR/BPS	7232
DrugBank	DB00340
ChemSpider	4023
UNII	32VY6L26ZW
KEGG	D08209
ChEBI	CHEBI:51024
ChEMBL	ChEMBL1201342
CompTox Dashboard(EPA)	DTXSID1047867
ECHA InfoCard	100.023.282
Chemical and physical data
Formula	C₂₀H₂₃NS
Molar mass	309.47 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
InChI InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3 Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N
^NY (what is this?) (verify)

Metixene (brand namesMethixart,CholinFall,Tremonil,Trest), also known asmethixene, is ananticholinergic used as anantiparkinsonian agent.^[2] It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases.^[3]

References

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^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
^Morton IK, Hall JM (1999)."Metixene".Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178.ISBN 978-94-011-4439-1.
^Fares, Jawad (2023)."Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases".Journal of Clinical Investigation.133 (24) e161142.doi:10.1172/JCI161142.PMC 10721147.PMID 37847564.

Antiparkinson agents (N04)

Dopaminergics

DA precursors	Levodopa^# (+benserazide,+carbidopa,+carbidopa/entacapone) Foslevodopa (+foscarbodipa) Melevodopa (+carbidopa)
DA receptor agonists	Ergoline:Bromocriptine Cabergoline Dihydroergocryptine Lisuride Pergolide Non-ergoline:Apomorphine Piribedil Pramipexole Ropinirole Rotigotine Talipexole
MAO-B inhibitors	Rasagiline Safinamide Selegiline
COMT inhibitors	Entacapone Opicapone Tolcapone
AAAD inhibitors	Benserazide (+levodopa) Carbidopa^# (+carbidopa,+melevodopa,+carbidopa/entacapone) Foscarbidopa (+foslevodopa)