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| Clinical data | |
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| Trade names | Oblivon |
| Other names | Methylparafynol |
| Routes of administration | By mouth |
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| ECHA InfoCard | 100.000.960 |
| Chemical and physical data | |
| Formula | C6H10O |
| Molar mass | 98.145 g·mol−1 |
| 3D model (JSmol) | |
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Methylpentynol (also known asmethylparafynol, trade namesDormison,Atemorin,Oblivon) is atertiary pentynol withhypnotic/sedative andanticonvulsant effects and an exceptionally lowtherapeutic index. It was discovered byBayer in 1913[2] and was used shortly thereafter for the treatment ofinsomnia, but its use was quickly phased out in response to newer drugs with far more favorable safety profiles.[3][4][5]
The drug was marketed again in the United States, Europe and elsewhere from 1956 well into the 1960s as a rapid-acting sedative.[6] The drug was quickly overshadowed at that point bybenzodiazepines and is no longer sold anywhere.[7]
Methylpentynol is prepared by reaction ofbutanone (MEK) with sodiumacetylide in liquidammonia. This reaction must be done in anhydrous conditions and in an inert atmosphere.
As building block in the synthesis of:
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