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| Clinical data | |
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| Other names | MOHN; MHN; 4-Hydroxy-17α-methyl-19-nortestosterone; HMNT; 4,17β-Dihydroxy-17α-methylestr-4-en-3-one |
| Routes of administration | By mouth[1] |
| Drug class | Androgen;Anabolic steroid |
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| Chemical and physical data | |
| Formula | C19H28O3 |
| Molar mass | 304.430 g·mol−1 |
| 3D model (JSmol) | |
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Methylhydroxynandrolone (MOHN,MHN), also known as4-hydroxy-17α-methyl-19-nortestosterone (HMNT), as well as4,17β-dihydroxy-17α-methylestr-4-en-3-one, is asynthetic,orally activeanabolic–androgenic steroid (AAS) and a17α-alkylatedderivative ofnandrolone (19-nortestosterone) which was never marketed.[1] It was first described in 1964 and was studied in the treatment ofbreast cancer, but was not introduced for clinical use.[1][2] The drug re-emerged in 2004 when it started being sold on theInternet as a "dietary supplement".[1] MOHN joined other AAS as acontrolled substance in theUnited States on 20 January 2005.[1]
MOHN is non-aromatizable due to the presence of ahydroxy group at the C4 position, and for this reason, poses no risk ofestrogenicside effects likegynecomastia at anydosage, unlike many other AAS.[1]5α-Reduction is also inhibited by the C4 hydroxy group of MOHN and, because of this, MOHN may have a relatively higher ratio ofandrogenic toanabolic activity than other nandrolone derivatives (as 5α-reduction, opposite to the case of most other AAS,decreases AASpotency for most nandrolone derivatives).[1] Earlyassays found that MOHN had approximately 13 times the anabolic activity and 3 times the androgenic activity ofmethyltestosterone.[1]
MOHN is the 4-hydroxylated derivative ofnormethandrone (17α-methyl-19-nortestosterone), the 17α-methylated derivative ofoxabolone (4-hydroxy-19-nortestosterone), the 4-hydroxylated and 17α-methylated derivative of nandrolone (19-nortestosterone), and the 19-demethylated analogue ofoxymesterone (4-hydroxy-17α-methyltestosterone).[1]
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