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Methylecgonine cinnamate

From Wikipedia, the free encyclopedia
Methylecgonine cinnamate
Names
IUPAC name
methyl (1R,2R,3S,5S)-8-methyl-3-[(E)-3-phenylprop-2-enoyl]oxy-8-azabicyclo[3.2.1]octane-2-carboxylate
Other names
Cinnamoylcocaine
Cinnamylcocaine
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C19H23NO4/c1-20-14-9-10-15(20)18(19(22)23-2)16(12-14)24-17(21)11-8-13-6-4-3-5-7-13/h3-8,11,14-16,18H,9-10,12H2,1-2H3/b11-8+/t14?,15?,16?,18-/m1/s1 checkY
    Key: MQIXMJWNEKUAOZ-GKMMPQBVSA-N checkY
  • InChI=1/C19H23NO4/c1-20-14-9-10-15(20)18(19(22)23-2)16(12-14)24-17(21)11-8-13-6-4-3-5-7-13/h3-8,11,14-16,18H,9-10,12H2,1-2H3/b11-8+/t14?,15?,16?,18-/m1/s1
    Key: MQIXMJWNEKUAOZ-GKMMPQBVBP
  • CN3C2CCC3CC(OC(=O)/C=C/c1ccccc1)[C@@H]2C(=O)OC
Properties
C19H23NO4
Molar mass329.396 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

Methylecgonine cinnamate is a naturaltropanealkaloid found within thecoca plant.[1] Its more common name,cinnamoylcocaine, reflects its close structural similarity tococaine. It is pharmacologically inactive,[2] but some studies funded by anti-drug agencies imply that it is active when smoked.[citation needed] Furthermore, the discovery of differing impurity products yielding methylecgonine cinnamate in confiscated cocaine have led enforcing agencies to postulate that illicit manufacturers have changed their oxidation procedures when refining cocaine from a crude form.[3] Methylecgonine cinnamate can dimerize to thetruxillic acidderivativetruxilline.[2] Methylecgonine cinnamate is mentioned in patents of active cocaine analogue structures.[4][5]

See also

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References

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  1. ^Plowman, T.; Rivier, L. (1983). "Cocaine and Cinnamoylcocaine Content of Erythroxylum Species".Annals of Botany.51 (5):641–659.doi:10.1093/oxfordjournals.aob.a086511.
  2. ^abMerck Chemical Index, 1985
  3. ^Casale, J. F.; Hays, P. A.; Toske, S. G.; Berrier, A. L. (Jul 2007). "Four new illicit cocaine impurities from the oxidation of crude cocaine base: formation and characterization of the diastereomeric 2,3-dihydroxy-3-phenylpropionylecgonine methyl esters from cis- and trans-cinnamoylcocaine".J Forensic Sci.52 (4):860–6.doi:10.1111/j.1556-4029.2007.00476.x.PMID 17553089.S2CID 43863333.
  4. ^U.S. patent 6,479,509 Patent inventor Frank Ivy Carroll, Assignee: Research Triangle Institute
  5. ^U.S. patent US6479509 B1 structures given for submission, 5th compound down in image.

External links

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