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| Formula | C12H20N2O2S2 |
| Molar mass | 288.42 g·mol−1 |
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Methitural (INN;Neraval,Thiogenal), ormethitural sodium, also known asmethioturiate, is abarbituratederivative which was marketed in the 1950s inEurope (inGermany andItaly) as an ultra-short-actingintravenousanesthetic.[1][2][3]
A somewhat more complex side chain is incorporated by alkylation of the carbanion of the substitutedcyanoacetate (1) with 2-chloroethylmethyl sulfide (2). Condensation of the resulting cyanoester (3) withthiourea followed by hydrolysis of the resulting imine affords methitural.
