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| Formula | C14H19N3S |
| Molar mass | 261.39 g·mol−1 |
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Methapyrilene is anantihistamine andanticholinergic of thepyridinechemical class which was developed in the early 1950s. It was sold under the trade names Co-Pyronil and Histadyl EC in the UK.[1] It has relatively strongsedative effects, to the extent that its primary use was as a medication forinsomnia rather than for its antihistamine action. Together withscopolamine, it was the main ingredient inSominex, Nytol, and Sleep-Eze. It also provided the sedative component of Excedrin PM.[2] All of these products were reformulated in the late 1970s[3] when methapyrilene was demonstrated to causeliver cancer in rats when given chronically.[4]
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