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| Trade names | Talis |
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| Formula | C18H18BrClN2O |
| Molar mass | 393.71 g·mol−1 |
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Metaclazepam[1] (marketed under the brand nameTalis) is a drug which is abenzodiazepine derivative.[2][3] It is a relatively selectiveanxiolytic with lesssedative ormuscle relaxant properties than other benzodiazepines such asdiazepam orbromazepam.[4] It has anactive metaboliteN-desmethylmetaclazepam, which is the mainmetabolite of metaclazepam.[5] There is no significant difference in metabolism between younger and older individuals.[6]
Metaclazepam is slightly more effective as an anxiolytic thanbromazepam,[7] ordiazepam,[8] with a 15 mg dose of metaclazepam equivalent to 4 mg of bromazepam.[9] Metaclazepam can interact withalcohol producing additive sedative-hypnotic effects.[6][10]Fatigue is a common side effect from metaclazepam at high doses.[11] Small amounts of metaclazepam as well as its metabolites enter into humanbreast milk.[12]
