 | |
| Names | |
|---|---|
| IUPAC name (1R,3R,4S)-p-Menthan-3-yl 3-methylbutanoate | |
| Systematic IUPAC name (1R,2S,5R)-5-Methyl-2-(propan-2-yl)cyclohexyl 3-methylbutanoate | |
| Other names Validolum; Valofin; Validol; Menthoval | |
| Identifiers | |
3D model (JSmol) | |
| ChemSpider | |
| ECHA InfoCard | 100.036.766 |
| UNII | |
| |
| |
| Properties | |
| C15H28O2 | |
| Molar mass | 240.387 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Menthyl isovalerate, also known asvalidolum, is thementhylester ofisovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble inethanol, while practically insoluble in water. It is used as afood additive forflavor and fragrance.[1]
In Poland, Bulgaria, Romania and the former Soviet Union states including Russia, menthyl isovalerate mixed with roughly 25% menthol is sold as ananxiolytic under various trade names including Extravalerianic, Validol, Valofin, and Menthoval.[2][3][4]
Validol, the anxiety medication containing a roughly 25% solution of menthol in menthyl isovalerate is prepared essentially in one step, in which the amount of menthol added before conducting the acid catalysed esterification is in an excess such that the resulting solution of the yielded ester has around 25% menthol, simplifying the procedure. Work up might consist of several washings, including one with aqueoussodium bicarbonate to neutralize traces of acid catalyst and unreacted isovaleric acid, anddistillation.[citation needed]
