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| ECHA InfoCard | 100.020.571 |
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| Formula | C22H30O3 |
| Molar mass | 342.479 g·mol−1 |
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Megestrol (INNTooltip International Nonproprietary Name,BANTooltip British Approved Name) is aprogestin of the17α-hydroxyprogesterone group which was, until recently, never marketed or used clinically.[1][2] It is now used for treatments ofdisease-related weight loss,endometrial cancer, andbreast cancer.[3] Itsacylated derivativemegestrol acetate is also aprogestogen, which, in contrast to megestrol itself, has been extensively used as apharmaceuticaldrug.[1][2]
As of June 2023, megestrol is being used to treat significant weight loss inHIV/AIDS patients, and as apalliative treatment ofendometrial andbreast cancers. It can be administered in both tablet and oral suspension forms, with dosages ranging from 100 mg/day to 1600 mg/day depending on the condition being treated.[3]
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