| Medical Sciences Building | |
|---|---|
![]() Interactive map of Medical Sciences Building | |
| General information | |
| Location | 1 King's College Cir Toronto, ON |
| Current tenants | Temerty Faculty of Medicine |
| Opening | 1969; 56 years ago (1969) |
| Owner | University of Toronto |
| Technical details | |
| Floor area | 33,837m2[1] |
| Other information | |
| Public transit access | |
| Designated | 2025 |
TheMedical Sciences Building (MSB) is the main medical school building of theTemerty Faculty of Medicine at theUniversity of Toronto. It was built in 1969 within the historic King's College Circle on theSt. George campus indowntown Toronto, Ontario, Canada. The large, predominantly concrete structure is exemplary of the Brutalist architectural style of the 1960s.[2] The building is connected to several others along College Street including the Donnelly Centre for Cellular and Biomolecular Research.[3]
The building is located in Toronto'sDiscovery District, home to several teaching hospitals partnered with the Temerty Faculty of Medicine, includingToronto General Hospital,Mount Sinai Hospital, andThe Hospital for Sick Children (SickKids).[4]

The site of the Medical Sciences Building has been used by the University of Toronto in science and medical education since as early as 1850. Part of a substantial expansion of the university post-World War II, several older buildings including theSchool of Practical Science built in 1878 (also known as "The Little Red Skulehouse"), were demolished in 1966 to accommodate its construction. It was completed in 1969.[5] The large building allowed theFaculty of Medicine to greatly expand its research capacity with new laboratory spaces.[6]
During the 2010s the MSB underwent a C$40 million renovation to modernize its facilities as part of a C$190 million Lab Innovation for Toronto project.[2]
In 2025, Toronto City Council adopted a by-law to designate the Medical Sciences Building under theOntario Heritage Act.[5]