Marvin H. Caruthers | |
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| Born | (1940-02-11)February 11, 1940 (age 86) Des Moines, Iowa, U.S. |
| Alma mater | Iowa State University,Northwestern University |
| Known for | DNA Synthesis |
| Scientific career | |
| Fields | Biochemistry |
| Institutions | University of Colorado Boulder |
| Thesis | The Synthesis of Oligothymidylate Derivatives on Insoluble Polymer Supports (1968) |
| Doctoral advisor | Robert L. Letsinger |
| Other academic advisors | Har Gobind Khorana,George Rathmann |
Marvin H. Caruthers (born February 11, 1940) is an Americanbiochemist who is adistinguished professor at theUniversity of Colorado Boulder.
Caruthers earned aB.S inchemistry at theIowa State University in 1962 and aPh.D. inbiochemistry 1968 atNorthwestern University with Robert Letsinger. He did his postdoctoral work atMassachusetts Institute of Technology withHar Gobind Khorana. From 1973 he was assistant professor and in 1980 professor of biochemistry at the University of Colorado at Boulder.
His research is on nucleic acids. He and his research group developed methods for the phosphoramidite synthesis of DNA.[1] Using this technique, his group was able to incorporate nucleotide analogs for functional group mutagenesis for a deeper understanding of nucleic acid biochemistry.[2][3] In addition to DNA, he developed methods of RNA synthesis and also for DNA analogues and the applications of the resulting molecules. He was a co-founder ofAmgen andApplied Biosystems withLeroy Hood.[4][5]
In 1994 Caruthers was elected a member of theNational Academy of Sciences[6] and a Fellow of theAmerican Academy of Arts and Sciences in 1994.[7] He received theNational Medal of Science (2006), the NAS Award for Chemistry in Service to Society (2005) and the NAS Award in Chemical Sciences (2014). In 1980 he was awarded aGuggenheim Fellowship.[8]
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