Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Manidipine

From Wikipedia, the free encyclopedia
Antihypertensive drug of the calcium channel blocker class

Pharmaceutical compound
Manidipine
Clinical data
Trade namesManyper, Caldine, etc.
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (±)-2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC35H38N4O6
Molar mass610.711 g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1cccc(c1)C5C(/C(=O)OC)=C(\N\C(=C5\C(=O)OCCN4CCN(C(c2ccccc2)c3ccccc3)CC4)C)C
  • InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,32-33,36H,17-22H2,1-3H3

Manidipine is acalcium channel blocker (dihydropyridine type) that is used clinically as anantihypertensive.[1][2][3][4][5]

It was patented in 1982 and approved for medical use in 1990.[6]

Synthesis

[edit]
Thieme Synthesis:[7] Patent:[8] Sino:[9][10][11][12][13][14][15]

The alkylation between N-(2-hydroxyethyl)piperazine [103-76-4] (1) and Benzhydryl Bromide [776-74-9] (2) gives 2-(4-benzhydrylpiperazin-1-yl)ethanol [10527-64-7] (3). The reaction with Diketene [674-82-8] (4) gives 2-(4-benzhydryl-1-piperazinyl)ethyl acetoacetate [89226-49-3] (5). The reaction with 3-nitrobenzaldehyde [99-61-6] (6) and Methyl 3-aminocrotonate [14205-39-1] (7) completed the synthesis of Manidipine (8).

References

[edit]
  1. ^Cheer SM, McClellan K (2001)."Manidipine: a review of its use in hypertension".Drugs.61 (12):1777–1799.doi:10.2165/00003495-200161120-00010.PMID 11693466.S2CID 260814599. Archived fromthe original on 2013-01-17. Retrieved2009-06-20.
  2. ^McKeage K, Scott LJ (2004)."Manidipine: a review of its use in the management of hypertension".Drugs.64 (17):1923–1940.doi:10.2165/00003495-200464170-00011.PMID 15329044.S2CID 195689527. Archived fromthe original on 2013-01-16. Retrieved2009-06-20.
  3. ^Roca-Cusachs A, Triposkiadis F (2005)."Antihypertensive effect of manidipine".Drugs.65 (Suppl 2):11–19.doi:10.2165/00003495-200565002-00003.PMID 16398058.S2CID 25854593. Archived fromthe original on 2013-01-16. Retrieved2009-06-20.
  4. ^Otero ML (2007)."Manidipine-delapril combination in the management of hypertension".Vascular Health and Risk Management.3 (3):255–263.PMC 2293964.PMID 17703633.
  5. ^Mizuno K, Haga H, Takahashi M, Fukuchi S (August 1992). "Evaluation of manidipine hydrochloride, a new calcium antagonist, in the treatment of hypertensive patients with renal disorders".Current Therapeutic Research.52 (2):248–253.doi:10.1016/S0011-393X(05)80475-8.
  6. ^Fischer J, Ganellin CR (2006).Analogue-based Drug Discovery. John Wiley & Sons. p. 465.ISBN 9783527607495.
  7. ^Meguro, Kanji; Aizawa, Masahiro; Sohda, Takashi; Kawamatsu, Yutaka; Nagaoka, Akinobu (1985). "New 1,4-dihydropyridine derivatives with potent and long-lasting hypotensive effect.". CHEMICAL & PHARMACEUTICAL BULLETIN. 33 (9): 3787–3797.ISSN 0009-2363. doi:10.1248/cpb.33.3787.
  8. ^EP0094159 idem Kanji Meguro & Akinobu Nagaoka, US4892875 (1990 to Takeda Pharmaceutical Co Ltd).
  9. ^ Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Maruti Ganpati Ghagare, WO20110203954 (2011 to Cipla Limited, Curtis, Philip Anthony).
  10. ^刘玉海, et al. CN105924382 (2018).
  11. ^金晓峰, et al. CN102875451 (2014 to CHANGZHOU PHARMACEUTICAL FACTORY CO LTD).
  12. ^刘忠春, CN107337632 (2017).
  13. ^谷志勇, et al. CN104292150 (2015).
  14. ^, CN103351362 (2013 to).
  15. ^http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHOU200402000.htm[permanent dead link]
Calcium
VDCCsTooltip Voltage-dependent calcium channels
Blockers
Activators
Potassium
VGKCsTooltip Voltage-gated potassium channels
Blockers
Activators
IRKsTooltip Inwardly rectifying potassium channel
Blockers
Activators
KCaTooltip Calcium-activated potassium channel
Blockers
Activators
K2PsTooltip Tandem pore domain potassium channel
Blockers
Activators
Sodium
VGSCsTooltip Voltage-gated sodium channels
Blockers
Activators
ENaCTooltip Epithelial sodium channel
Blockers
Activators
ASICsTooltip Acid-sensing ion channel
Blockers
Chloride
CaCCsTooltip Calcium-activated chloride channel
Blockers
Activators
CFTRTooltip Cystic fibrosis transmembrane conductance regulator
Blockers
Activators
Unsorted
Blockers
Others
TRPsTooltip Transient receptor potential channels
LGICsTooltip Ligand gated ion channels
Phenylpiperazines
Benzylpiperazines
Naphthylpiperazines
Quinolinylpiperazines
Diphenylalkylpiperazines
Pyrimidinylpiperazines
Pyridinylpiperazines
Benzo(iso)thiazolylpiperazines
Tricyclic-linked piperazines
Others/uncategorized
Stub icon

Thisdrug article relating to thecardiovascular system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Manidipine&oldid=1318748765"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp