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| Macroglobulinemia | |
|---|---|
| Specialty | Hematology |
Macroglobulinemia is the presence of increased levels ofmacroglobulins in the circulatingblood.It is aplasma cell dyscrasia, resemblingleukemia, with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete a monoclonalimmunoglobulin M component. There is diffuse infiltration by the malignant cells of the bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin can produce symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence of macroglobulinemia is in the sixth and seventh decades of life. (Dorland, 28th ed)
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