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MYT1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens

MYT1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2JX1,2JYD,2MF8

Identifiers
AliasesMYT1, C20orf36, MTF1, MYTI, NZF2, PLPB1, ZC2HC4A, ZC2H2C1, myelin transcription factor 1
External IDsOMIM:600379;MGI:1100535;HomoloGene:3332;GeneCards:MYT1;OMA:MYT1 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for MYT1
Genomic location for MYT1
Band20q13.33Start64,102,394bp[1]
End64,242,253bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for MYT1
Genomic location for MYT1
Band2 H4|2 103.77 cMStart181,763,332bp[2]
End181,827,797bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • cerebellum

  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • hypothalamus

  • amygdala

  • substantia nigra

  • nucleus accumbens

  • testicle

  • islet of Langerhans
Top expressed in
  • lumbar spinal ganglion

  • Rostral migratory stream

  • ganglionic eminence

  • neural layer of retina

  • ventricular zone

  • medial ganglionic eminence

  • zygote

  • autonomic nervous system

  • superior cervical ganglion

  • trigeminal ganglion
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4661

17932

Ensembl

ENSG00000196132

ENSMUSG00000010505

UniProt

Q01538

Q8CFC2

RefSeq (mRNA)

NM_004535

NM_001171615
NM_001171616
NM_001171680
NM_008665

RefSeq (protein)

NP_004526

NP_001165086
NP_001165087
NP_001165151
NP_032691

Location (UCSC)Chr 20: 64.1 – 64.24 MbChr 2: 181.76 – 181.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myelin transcription factor 1 is aprotein that in humans is encoded by theMYT1gene.[5][6][7]

Function

[edit]

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[7]

Interactive pathway map

[edit]

Click on genes, proteins and metabolites below to visit related articles.[§ 1]

  1. ^The interactive pathway map can be edited at WikiPathways:"WP3584".

Interactions

[edit]

MYT1 has been shown tointeract withPIN1.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000196132Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000010505Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Kim JG, Hudson LD (December 1992)."Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene".Molecular and Cellular Biology.12 (12):5632–9.doi:10.1128/mcb.12.12.5632.PMC 360502.PMID 1280325.
  6. ^Booher RN, Holman PS, Fattaey A (August 1997)."Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity".The Journal of Biological Chemistry.272 (35):22300–6.doi:10.1074/jbc.272.35.22300.PMID 9268380.
  7. ^ab"Entrez Gene: MYT1 myelin transcription factor 1".
  8. ^Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (October 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression".Journal of Cell Science.112 (19):3361–71.doi:10.1242/jcs.112.19.3361.PMID 10504341.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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