Movatterモバイル変換

[0]ホーム

Jump to content

MYO18B

Edit links

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

MYO18B

Identifiers

Aliases

MYO18B, KFS4, myosin XVIIIB

External IDs

OMIM:607295;MGI:1921626;HomoloGene:53435;GeneCards:MYO18B;OMA:MYO18B - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q12.1	Start	25,742,144bp^[1]
Band	22q12.1	End	26,031,045bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 F	Start	112,836,742bp^[2]
Band	5\|5 F	End	113,044,228bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

apex of heart

gastrocnemius muscle

muscle of thigh

Skeletal muscle tissue of rectus abdominis

left ventricle

Skeletal muscle tissue of biceps brachii

right auricle of heart

quadriceps femoris muscle

vastus lateralis muscle

right ventricle

Top expressed in

muscle of thigh

esophagus

spermatid

skeletal muscle tissue

lens

embryo

quadriceps femoris muscle

superior frontal gyrus

heart

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding actin binding cytoskeletal motor activity ATP binding microtubule motor activity microtubule binding
Cellular component	cytoplasm unconventional myosin complex sarcomere nucleus myosin complex Z discdkac filamentous actin
Biological process	microtubule-based movement vasculogenesis in utero embryonic development
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


84700


74376

Ensembl


ENSG00000133454


ENSMUSG00000072720

UniProt


Q8IUG5


n/a

RefSeq (mRNA)


NM_032608 NM_001318245


NM_028901

RefSeq (protein)


NP_001305174 NP_115997


n/a

Location (UCSC)

Chr 22: 25.74 – 26.03 Mb

Chr 5: 112.84 – 113.04 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-XVIIIb is aprotein that in humans is encoded by theMYO18Bgene.^[5]^[6]^[7]

The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000133454 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000072720 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nishioka M, Kohno T, Tani M, Yanaihara N, Tomizawa Y, Otsuka A, Sasaki S, Kobayashi K, Niki T, Maeshima A, Sekido Y, Minna JD, Sone S, Yokota J (Sep 2002)."MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer".Proc Natl Acad Sci U S A.99 (19):12269–74.Bibcode:2002PNAS...9912269N.doi:10.1073/pnas.192445899.PMC 129434.PMID 12209013.
^Salamon M, Millino C, Raffaello A, Mongillo M, Sandri C, Bean C, Negrisolo E, Pallavicini A, Valle G, Zaccolo M, Schiaffino S, Lanfranchi G (Jan 2003). "Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation".J Mol Biol.326 (1):137–49.doi:10.1016/S0022-2836(02)01335-9.PMID 12547197.
^^a ^b"Entrez Gene: MYO18B myosin XVIIIB".

Yokota J, Nishioka M, Tani M, Kohno T (2003). "Genetic alterations responsible for metastatic phenotypes of lung cancer cells".Clin. Exp. Metastasis.20 (3):189–93.doi:10.1023/A:1022978932215.PMID 12741677.S2CID 22741542.
Dunham I, Shimizu N, Roe BA, et al. (1999)."The DNA sequence of human chromosome 22".Nature.402 (6761):489–95.Bibcode:1999Natur.402..489D.doi:10.1038/990031.PMID 10591208.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Yanaihara N, Nishioka M, Kohno T, et al. (2004)."Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer".Int. J. Cancer.112 (1):150–4.doi:10.1002/ijc.20339.PMID 15305387.S2CID 25091930.
Inoue T, Kon T, Ajima R, et al. (2006). "MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway".Biochem. Biophys. Res. Commun.342 (3):829–34.doi:10.1016/j.bbrc.2006.02.025.PMID 16499872.
Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.
Edakuni N, Ikuta K, Yano S, et al. (2007)."Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice".Oncol. Res.16 (5):235–43.doi:10.3727/000000006783981062.PMID 17294804.

Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3