| Myosin light chain kinase family, member 4 | |||||||
|---|---|---|---|---|---|---|---|
 The crystal structure of the human myosin light chain kinase Loc340156.[1] | |||||||
| Identifiers | |||||||
| Symbol | MYLK4 | ||||||
| NCBI gene | 340156 | ||||||
| HGNC | 27972 | ||||||
| RefSeq | NM_001012418 | ||||||
| UniProt | Q86YV6 | ||||||
| Other data | |||||||
| EC number | 2.7.11.18 | ||||||
| Locus | Chr. 6p25.2 | ||||||
| |||||||
Myosin light chain kinase 4 also known asMYLK4 is anenzyme which in humans is encoded by theMYLK2gene.[2] MYLK4 is a member of themyosin light-chain kinase family ofserine/threonine-specific protein kinases thatphosphorylate the regulatory light chain ofmyosin II.[3]
This protein acts as an enzyme that catalyzes the following reaction: ATP + a protein -> ADP + a phosphoprotein.[4]
MYLK4 is also involved in protein amino acid phosphorylation meaning that it adds a phosphate group onto the molecule.[5]
Not very much is known about the specific functional characteristics of MLYK4, but it has recently been found that the gene may possibly have a role in having at least one driver mutation for cancer.[6]MYLK4 may also be involved in transferase activity, ATP binding, protein serine/threonine kinase activity, and also nucleotide binding.[7]Other names for MYLK4 are CaMLCK like; EG238564; MYLK4; Mylk4; Myosin light chain kinase family, member 4; SgK085; SGK085; Sgk085; Sugen kinase 85; Uncharacterized serine/threonine-protein kinase SgK085.[8]
There are other knownmyosin light-chain kinase enzymes.
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