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MYLK3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

MYLK3

Identifiers

Aliases

MYLK3, MLCK, MLCK2, caMLCK, myosin light chain kinase 3

External IDs

OMIM:612147;MGI:2443063;HomoloGene:35278;GeneCards:MYLK3;OMA:MYLK3 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q11.2	Start	46,702,282bp^[1]
Band	16q11.2	End	46,790,407bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 C3	Start	86,050,932bp^[2]
Band	8\|8 C3	End	86,112,974bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cardiac muscle tissue of right atrium

right ventricle

myocardium of left ventricle

right auricle

Skeletal muscle tissue of biceps brachii

body of tongue

apex of heart

thoracic diaphragm

Skeletal muscle tissue of rectus abdominis

triceps brachii muscle

Top expressed in

myocardium of ventricle

atrium

interventricular septum

atrioventricular valve

epithelium of small intestine

esophagus

migratory enteric neural crest cell

endocardial cushion

left ventricle

bone marrow

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	calmodulin-dependent protein kinase activity kinase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity transferase activity ATP binding myosin light chain kinase activity
Cellular component	cytoplasm actin cytoskeleton cytosol intracellular anatomical structure
Biological process	protein phosphorylation positive regulation of sarcomere organization regulation of vascular permeability involved in acute inflammatory response sarcomere organization cellular response to interleukin-1 phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation intracellular signal transduction sarcomerogenesis cardiac myofibril assembly
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


91807


213435

Ensembl


ENSG00000140795


ENSMUSG00000031698

UniProt


Q32MK0


Q3UIZ8

RefSeq (mRNA)


NM_001308301 NM_182493


NM_001297612 NM_175441

RefSeq (protein)


NP_001295230 NP_872299


NP_001284541 NP_780650

Location (UCSC)

Chr 16: 46.7 – 46.79 Mb

Chr 8: 86.05 – 86.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin light chain kinase 3 also known asMYLK3, is anenzyme which in humans is encoded by theMYLK3gene.^[5]^[6]

Function

[edit]

Phosphorylation of cardiacmyosin heavy chains (seeMYH7B) and light chains (seeMYL2) by akinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiacmyocytes.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000140795 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000031698 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: MLCK MLCK protein".
^Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007)."A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart".J. Clin. Invest.117 (10):2812–24.doi:10.1172/JCI30804.PMC 1978424.PMID 17885681.
^Chan JY, Takeda M, Briggs LE, Graham ML, Lu JT, Horikoshi N, Weinberg EO, Aoki H, Sato N, Chien KR, Kasahara H (March 2008)."Identification of cardiac-specific myosin light chain kinase".Circ. Res.102 (5):571–80.doi:10.1161/CIRCRESAHA.107.161687.PMC 2504503.PMID 18202317.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Clayburgh DR, Rosen S, Witkowski ED, et al. (2005)."A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability".J. Biol. Chem.279 (53):55506–13.doi:10.1074/jbc.M408822200.PMC 1237105.PMID 15507455.
Wang F, Graham WV, Wang Y, et al. (2005)."Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression".Am. J. Pathol.166 (2):409–19.doi:10.1016/S0002-9440(10)62264-X.PMC 1237049.PMID 15681825.
Russo JM, Florian P, Shen L, et al. (2005)."Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure".Gastroenterology.128 (4):987–1001.doi:10.1053/j.gastro.2005.01.004.PMC 1237051.PMID 15825080.
Shimizu S, Yoshida T, Wakamori M, et al. (2006)."Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells".J. Physiol.570 (Pt 2):219–35.doi:10.1113/jphysiol.2005.097998.PMC 1464317.PMID 16284075.
Kim MT, Kim BJ, Lee JH, et al. (2006). "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells".Am. J. Physiol., Cell Physiol.290 (4): C1031–40.doi:10.1152/ajpcell.00602.2004.PMID 16306123.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.
Connell LE, Helfman DM (2007)."Myosin light chain kinase plays a role in the regulation of epithelial cell survival".J. Cell Sci.119 (Pt 11):2269–81.doi:10.1242/jcs.02926.PMID 16723733.
Seguchi O, Takashima S, Yamazaki S, et al. (2007)."A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart".J. Clin. Invest.117 (10):2812–24.doi:10.1172/JCI30804.PMC 1978424.PMID 17885681.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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MYLK3

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See also

References

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