Myosin light chain kinase 2 also known asMYLK2 is anenzyme which in humans is encoded by theMYLK2gene.[5]
This gene encodes amyosin light chain kinase, acalcium /calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle.[6] The MYLK2 gene expresses skMLCK more prevalently in fast twitch muscle fibers as compared to slow twitch muscle fibers. Calmodulin is composed of two terminal domains (N,C) each containing two E-F hand motifs that bind to Ca2+. Upon saturation of Ca2+, Calmodulin undergoes a conformation change allowing it to bind with a target protein such as skMLCK. An image depicting a similar complex (sdCen/skMLCK2) is shown undermyosin light chain kinase. This binding to skMLCK increases the affinity of Ca2+ and ultimately leads to a sustained muscle action.[7]
Mutations in theMYLK2 gene have been linked to midventricularhypertrophic cardiomyopathy.[5]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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