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MYH15

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

MYH15

Identifiers

Aliases

MYH15, myosin heavy chain 15

External IDs

OMIM:609929;MGI:3643515;HomoloGene:18929;GeneCards:MYH15;OMA:MYH15 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q13.13	Start	108,380,368bp^[1]
Band	3q13.13	End	108,529,322bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 B5	Start	48,877,849bp^[2]
Band	16\|16 B5	End	49,019,467bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

paraflocculus of cerebellum

frontal pole

middle frontal gyrus

gonad

testicle

optic nerve

C1 segment

rectum

prefrontal cortex

cingulate gyrus

Top expressed in

spermatid

secondary oocyte

testicle

primary oocyte

zygote

lens

dentate gyrus of hippocampal formation granule cell

hypothalamus

striatum of neuraxis

hippocampus proper

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding actin binding cytoskeletal motor activity ATP binding calmodulin binding actin filament binding microtubule motor activity microtubule binding
Cellular component	cytoplasm myosin filament myofibril myosin complex
Biological process	extraocular skeletal muscle development microtubule-based movement
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


22989


667772

Ensembl


ENSG00000144821


ENSMUSG00000092009

UniProt


Q9Y2K3


E9Q264

RefSeq (mRNA)


NM_014981


NM_001166210

RefSeq (protein)


NP_055796


NP_001159682

Location (UCSC)

Chr 3: 108.38 – 108.53 Mb

Chr 16: 48.88 – 49.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-15 also known asmyosin, heavy chain 15 is aprotein that in humans is encoded by theMYH15gene.^[5]

Function

[edit]

MYH15 is aslow-twitch myosin.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000144821 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000092009 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bDesjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002)."Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family".Mol. Biol. Evol.19 (4):375–93.doi:10.1093/oxfordjournals.molbev.a004093.PMID 11919279.

Luke MM, O'Meara ES, Rowland CM, et al. (2009)."Gene variants associated with ischemic stroke: the cardiovascular health study".Stroke.40 (2):363–8.doi:10.1161/STROKEAHA.108.521328.PMC 2881155.PMID 19023099.
Rossi AC, Mammucari C, Argentini C, et al. (2010)."Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles".J. Physiol.588 (Pt 2):353–64.doi:10.1113/jphysiol.2009.181008.PMC 2821527.PMID 19948655.
Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.
Stedman HH, Kozyak BW, Nelson A, et al. (2004). "Myosin gene mutation correlates with anatomical changes in the human lineage".Nature.428 (6981):415–8.Bibcode:2004Natur.428..415S.doi:10.1038/nature02358.PMID 15042088.S2CID 4304466.
Nagase T, Ishikawa K, Suyama M, et al. (1999)."Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.6 (1):63–70.doi:10.1093/dnares/6.1.63.PMID 10231032.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
McGuigan K, Phillips PC, Postlethwait JH (2004)."Evolution of sarcomeric myosin heavy chain genes: evidence from fish".Mol. Biol. Evol.21 (6):1042–56.doi:10.1093/molbev/msh103.PMID 15014174.
Shiffman D, O'Meara ES, Bare LA, et al. (2008)."Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study".Arterioscler. Thromb. Vasc. Biol.28 (1):173–9.doi:10.1161/ATVBAHA.107.153981.PMC 2636623.PMID 17975119.
Bare LA, Morrison AC, Rowland CM, et al. (2007)."Five common gene variants identify elevated genetic risk for coronary heart disease".Genet. Med.9 (10):682–9.doi:10.1097/GIM.0b013e318156fb62.PMID 18073581.

Proteins of thecytoskeleton

Human

Microfilaments
andABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
andMAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal:DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic:DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3