The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.[6] MYBL2 is deregulated in various cancer types and can contribute to cancer progression.[7][8]
^Joaquin M, Bessa M, Saville MK, Watson RJ (November 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107".Oncogene.21 (52):7923–32.doi:10.1038/sj.onc.1206001.PMID12439743.S2CID21761703.
Golay J, Cusmano G, Introna M (July 1992). "Independent regulation of c-myc, B-myb, and c-myb gene expression by inducers and inhibitors of proliferation in human B lymphocytes".Journal of Immunology.149 (1):300–8.doi:10.4049/jimmunol.149.1.300.PMID1376749.
Reiss K, Travali S, Calabretta B, Baserga R (September 1991). "Growth regulated expression of B-myb in fibroblasts and hematopoietic cells".Journal of Cellular Physiology.148 (3):338–43.doi:10.1002/jcp.1041480303.PMID1717494.S2CID30389377.
Zhou W, Takuwa N, Kumada M, Takuwa Y (February 1994). "E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells".Biochemical and Biophysical Research Communications.199 (1):191–8.doi:10.1006/bbrc.1994.1213.PMID8123011.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Saville MK, Watson RJ (November 1998). "The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties".Oncogene.17 (21):2679–89.doi:10.1038/sj.onc.1202503.PMID9840932.S2CID23576308.
Bartsch O, Horstmann S, Toprak K, Klempnauer KH, Ferrari S (March 1999). "Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb".European Journal of Biochemistry.260 (2):384–91.doi:10.1046/j.1432-1327.1999.00191.x.PMID10095772.
