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MT-7716

From Wikipedia, the free encyclopedia
Nociceptin receptor agonist
MT-7716
Names
IUPAC name
2-[3-[1-[(1R)-1,2-Dihydroacenaphthylen-1-yl]piperidin-4-yl]-2-oxobenzimidazol-1-yl]-N-methylacetamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C27H28N4O2/c1-28-25(32)17-30-22-10-2-3-11-23(22)31(27(30)33)20-12-14-29(15-13-20)24-16-19-8-4-6-18-7-5-9-21(24)26(18)19/h2-11,20,24H,12-17H2,1H3,(H,28,32)/t24-/m1/s1
    Key: PJANMOWVUZBDQF-XMMPIXPASA-N
  • CNC(=O)CN1C2=CC=CC=C2N(C1=O)C3CCN(CC3)[C@@H]4CC5=CC=CC6=C5C4=CC=C6
Properties
C27H28N4O2
Molar mass440.547 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

MT-7716 is an experimental opioid drug that could potentially be used in the treatment of alcohol addiction.

Mechanism of action

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Unlike most opioids, MT-7716 does not appear to act through delta, kappa and mu opioid receptors, but instead is an agonist of thenociceptin receptor.[1]

Alcohol addiction

[edit]

A study has shown that MT-7716 was able to decrease alcohol self-administration and reduce alcohol withdrawal symptoms in rats.[2]

Another study was also able to show similar results, in addition to demonstrating MT-7716's ability to suppress stress-induced alcohol seeking.[3]

References

[edit]
  1. ^Kallupi, Marsida; Oleata, Christopher S.; Luu, George; Teshima, Koji; Ciccocioppo, Roberto; Roberto, Marisa (2014)."MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala".Frontiers in Integrative Neuroscience.8: 18.doi:10.3389/fnint.2014.00018.ISSN 1662-5145.PMC 3927450.PMID 24600360.
  2. ^Ciccocioppo, Roberto; Stopponi, Serena; Economidou, Daina; Kuriyama, Makoto; Kinoshita, Hiroshi; Heilig, Markus; Roberto, Marisa; Weiss, Friedbert; Teshima, Koji (April 2014)."Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat".Neuropsychopharmacology.39 (11):2601–2610.doi:10.1038/npp.2014.113.ISSN 1740-634X.PMC 4207340.PMID 24863033.
  3. ^de Guglielmo, Giordano; Martin-Fardon, Rémi; Teshima, Koji; Ciccocioppo, Roberto; Weiss, Friedbert (July 2015)."MT-7716, a potent NOP receptor agonist, preferentially reduces ethanol seeking and reinforcement in post-dependent rats".Addiction Biology.20 (4):643–651.doi:10.1111/adb.12157.ISSN 1355-6215.PMC 4268094.PMID 24930632.
μ-opioid
(MOR)
Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
κ-opioid
(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
Antagonists
Others
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