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MNX1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MNX1
Identifiers
AliasesMNX1, HB9, HLXB9, HOXHB9, SCRA1, motor neuron and pancreas homeobox 1
External IDsOMIM:142994;MGI:109160;HomoloGene:21137;GeneCards:MNX1;OMA:MNX1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MNX1
Genomic location for MNX1
Band7q36.3Start156,994,051bp[1]
End157,010,663bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for MNX1
Genomic location for MNX1
Band5|5 B1Start29,678,032bp[2]
End29,683,468bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of pancreas

  • gonad

  • mucosa of transverse colon

  • testicle

  • beta cell

  • mucosa of sigmoid colon

  • duodenum

  • jejunal mucosa

  • rectum

  • mucosa of ileum
Top expressed in
  • lumbar subsegment of spinal cord

  • islet of Langerhans

  • female urethra

  • embryo

  • endoderm

  • notochord

  • embryonic organizer

  • tail of embryo

  • pharynx

  • neural tube
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3110

15285

Ensembl

ENSG00000130675

ENSMUSG00000001566

UniProt

P50219

A2RSX2

RefSeq (mRNA)

NM_005515
NM_001165255

NM_019944

RefSeq (protein)

NP_001158727
NP_005506

NP_064328

Location (UCSC)Chr 7: 156.99 – 157.01 MbChr 5: 29.68 – 29.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Motor neuron and pancreas homeobox 1 (MNX1), also known asHomeobox HB9 (HLXB9), is a humanprotein encoded by theMNX1gene.[5]

Clinical significance

[edit]

Mutations in theMNX1 gene are associated withCurrarino syndrome.[6] Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000130675Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000001566Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: HLXB9 homeobox HB9".
  6. ^Merello E, De Marco P, Ravegnani M, Riccipetitoni G, Cama A, Capra V (2013). "Novel MNX1 mutations and clinical analysis of familial and sporadic Currarino cases".Eur J Med Genet.56 (12):648–54.doi:10.1016/j.ejmg.2013.09.011.PMID 24095820.
  7. ^ Zhang, W., Huang, L., Lu, X., Wang, K., Ning, X., & Liu, Z. (2019). Upregulated expression of MNX1-AS1 long noncoding RNA predicts poor prognosis in gastric cancer. Bosnian journal of basic medical sciences, 19(2), 164–171.https://doi.org/10.17305/bjbms.2019.3713

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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