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ML-SI3

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
ML-SI3
Identifiers
  • N-[(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl]benzenesulfonamide
CAS Number
PubChemCID
ChemSpider
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC23H31N3O3S
Molar mass429.58 g·mol−1
3D model (JSmol)
  • COC1=CC=CC=C1N2CCN(CC2)[C@H]3CCCC[C@@H]3NS(=O)(=O)C4=CC=CC=C4
  • InChI=1S/C23H31N3O3S/c1-29-23-14-8-7-13-22(23)26-17-15-25(16-18-26)21-12-6-5-11-20(21)24-30(27,28)19-9-3-2-4-10-19/h2-4,7-10,13-14,20-21,24H,5-6,11-12,15-18H2,1H3/t20-,21-/m0/s1
  • Key:OVTXOMMQHRIKGL-SFTDATJTSA-N

ML-SI3 is a chemical compound which acts as an "antagonist" (i.e. channel blocker) of theTRPML family of calcium channels, with greatest activity at theTRPML1 channel, although it also blocks the relatedTRPML2 andTRPML3 channels with lower affinity. It is used for research into the role of TRPML1 and its various functions inlysosomes and elsewhere in the body.[1][2][3][4][5][6][7]

See also

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References

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  1. ^Kilpatrick BS, Yates E, Grimm C, Schapira AH, Patel S (October 2016)."Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx".Journal of Cell Science.129 (20):3859–3867.doi:10.1242/jcs.190322.PMC 5087663.PMID 27577094.
  2. ^Li X, Rydzewski N, Hider A, Zhang X, Yang J, Wang W, et al. (April 2016)."A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation".Nature Cell Biology.18 (4):404–17.doi:10.1038/ncb3324.hdl:2027.42/120892.PMC 4871318.PMID 26950892.
  3. ^Sahoo N, Gu M, Zhang X, Raval N, Yang J, Bekier M, et al. (May 2017)."2+ Efflux Channel in the Tubulovesicle".Developmental Cell.41 (3): 262–273.e6.doi:10.1016/j.devcel.2017.04.003.PMC 5497767.PMID 28486130.
  4. ^Scotto Rosato A, Montefusco S, Soldati C, Di Paola S, Capuozzo A, Monfregola J, Polishchuk E, Amabile A, Grimm C, Lombardo A, De Matteis MA, Ballabio A, Medina DL (December 2019)."TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway".Nature Communications.10 (1): 5630.Bibcode:2019NatCo..10.5630S.doi:10.1038/s41467-019-13572-w.PMC 6904751.PMID 31822666.
  5. ^Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, et al. (May 2019)."Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR".PLOS Biology.17 (5) e3000252.doi:10.1371/journal.pbio.3000252.PMC 6528971.PMID 31112550.
  6. ^Li D, Shao R, Wang N, Zhou N, Du K, Shi J, et al. (March 2020)."Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress".Autophagy.17 (4):872–887.doi:10.1080/15548627.2020.1739442.PMC 8078734.PMID 32138578.
  7. ^Leser C, Keller M, Gerndt S, Urban N, Chen CC, Schaefer M, Grimm C, Bracher F (October 2020). "Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3".European Journal of Medicinal Chemistry.210 112966.doi:10.1016/j.ejmech.2020.112966.PMID 33187805.
TRPA
Activators
Blockers
TRPC
Activators
Blockers
TRPM
Activators
Blockers
TRPML
Activators
Blockers
TRPP
Activators
Blockers
TRPV
Activators
Blockers
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