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MK6-83

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Chemical compound

Pharmaceutical compound

MK6-83
Identifiers

IUPAC name 5-methyl-N-[2-(piperidin-1-yl)phenyl]thiophene-2-sulfonamide
CAS Number	1062271-24-2^Y
PubChemCID	18191179
ChemSpider	17030252
UNII	RE9JUR6NT4
CompTox Dashboard(EPA)	DTXSID501336629
Chemical and physical data
Formula	C₁₆H₂₀N₂O₂S₂
Molar mass	336.47 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC=C(S1)S(=O)(=O)NC2=CC=CC=C2N3CCCCC3
InChI InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3 Key:IRGYSXZCDAWOOC-UHFFFAOYSA-N

MK6-83 is a chemical compound which acts as a channel opener for theTRPML family of calcium channels, with moderate selectivity forTRPML1 over the relatedTRPML2 andTRPML3 subtypes.^[1]^[2]^[3]

References

[edit]

^Kilpatrick BS, Yates E, Grimm C, Schapira AH, Patel S (October 2016)."Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx".Journal of Cell Science.129 (20):3859–3867.doi:10.1242/jcs.190322.PMC 5087663.PMID 27577094.
^Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G (April 2019)."Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival".Cancers.11 (4).doi:10.3390/cancers11040525.PMC 6521337.PMID 31013784.
^Xia Z, Wang L, Li S, Tang W, Sun F, Wu Y, et al. (October 2020). "ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity".Antiviral Research.182 104922.doi:10.1016/j.antiviral.2020.104922.PMID 32858116.

TRP channel modulators

TRPA

Activators

4-Hydroxynonenal
4-Oxo-2-nonenal
5,6-EET
12S-HpETE
15-Deoxy-Δ^12,14-prostaglandin J2
α-Sanshool (ginger,Sichuan andmelegueta peppers)
Acrolein
Allicin (garlic)
Allyl isothiocyanate (mustard,radish,horseradish,wasabi)
AM404
ASP-7663
Bradykinin
Cannabichromene (cannabis)
Cannabidiol (cannabis)
Cannabigerol (cannabis)
Cinnamaldehyde (cinnamon)
CR gas (dibenzoxazepine; DBO)
CS gas (2-chlorobenzal malononitrile)
Cuminaldehyde (cumin)
Curcumin (turmeric)
Dehydroligustilide (celery)
Diallyl disulfide
Dicentrine (Lindera spp.)
Farnesyl thiosalicylic acid
Formalin
Gingerols (ginger)
Hepoxilin A3
Hepoxilin B3
Hydrogen peroxide
Icilin
Isothiocyanate
JT-010
Ligustilide (celery,Angelica acutiloba)
Linalool (Sichuan pepper,thyme)
Methylglyoxal
Methyl salicylate (wintergreen)
N-Methylmaleimide
Nicotine (tobacco)
Oleocanthal (olive oil)
Paclitaxel (Pacific yew)
PF-4840154
Phenacyl chloride
Polygodial (Dorrigo pepper)
Shogaols (ginger,Sichuan andmelegueta peppers)
Tear gases
Tetrahydrocannabinol (cannabis)
Tetrahydrocannabiorcol
Thiopropanal S-oxide (onion)
Umbellulone (Umbellularia californica)
WIN 55,212-2

Blockers

TRPC

Activators	Adhyperforin (St John's wort) Diacyl glycerol GSK1702934A Hyperforin (St John's wort) Substance P
Blockers	DCDPC DHEA-S Flufenamic acid GSK417651A GSK2293017A Meclofenamic acid N-(p-Amylcinnamoyl)anthranilic acid Niflumic acid Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid

TRPM

Activators	ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10 Eucalyptol (eucalyptus) Frescolat MGA Frescolat ML Geraniol Hydroxycitronellal Icilin Linalool Menthol (mint) PMD 38 Pregnenolone sulfate Rutamarin (Ruta graveolens) Steviol glycosides (e.g.,stevioside) (Stevia rebaudiana) Sweettastants (e.g.,glucose,fructose,sucrose; indirectly) Thio-BCTC WS-12
Blockers	AMG-333 Capsazepine Clotrimazole DCDPC Elismetrep Flufenamic acid Meclofenamic acid Mefenamic acid N-(p-Amylcinnamoyl)anthranilic acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078 Ruthenium red Rutamarin (Ruta graveolens) Tolfenamic acid TPPO TRPM4-IN-5