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MEF2D

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MEF2D
Identifiers
AliasesMEF2D, myocyte enhancer factor 2D
External IDsOMIM:600663;MGI:99533;HomoloGene:4327;GeneCards:MEF2D;OMA:MEF2D - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MEF2D
Genomic location for MEF2D
Band1q22Start156,463,727bp[1]
End156,500,779bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MEF2D
Genomic location for MEF2D
Band3 F1|3 38.78 cMStart88,049,679bp[2]
End88,079,393bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • muscle of thigh

  • gastrocnemius muscle

  • popliteal artery

  • tibial arteries

  • saphenous vein

  • apex of heart

  • sural nerve

  • gastric mucosa

  • canal of the cervix

  • right coronary artery
Top expressed in
  • Ileal epithelium

  • neural layer of retina

  • perirhinal cortex

  • entorhinal cortex

  • CA3 field

  • muscle of thigh

  • dentate gyrus of hippocampal formation granule cell

  • superior frontal gyrus

  • plantaris muscle

  • primary visual cortex
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4209

17261

Ensembl

ENSG00000116604

ENSMUSG00000001419

UniProt

Q14814

Q63943

RefSeq (mRNA)

NM_001271629
NM_005920

NM_133665
NM_001310587
NM_001310593

RefSeq (protein)

NP_001258558
NP_005911

NP_001297516
NP_001297522
NP_598426

Location (UCSC)Chr 1: 156.46 – 156.5 MbChr 3: 88.05 – 88.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myocyte-specific enhancer factor 2D is aprotein that in humans is encoded by theMEF2Dgene.[5][6]

Interactions

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MEF2D has been shown tointeract with:

See also

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References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000116604Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000001419Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B (Aug 1993). "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage".Development.118 (4):1095–1106.doi:10.1242/dev.118.4.1095.PMID 8269842.
  6. ^"Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)".
  7. ^abYoun HD, Liu JO (Jul 2000)."Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2".Immunity.13 (1):85–94.doi:10.1016/s1074-7613(00)00010-8.PMID 10933397.
  8. ^Youn HD, Sun L, Prywes R, Liu JO (Oct 1999). "Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2".Science.286 (5440):790–793.doi:10.1126/science.286.5440.790.PMID 10531067.
  9. ^Youn HD, Grozinger CM, Liu JO (Jul 2000)."Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4".The Journal of Biological Chemistry.275 (29):22563–22567.doi:10.1074/jbc.C000304200.PMID 10825153.
  10. ^Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (Oct 1998)."Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1".Nucleic Acids Research.26 (20):4771–4777.doi:10.1093/nar/26.20.4771.PMC 147902.PMID 9753748.
  11. ^Ornatsky OI, McDermott JC (Oct 1996)."MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells".The Journal of Biological Chemistry.271 (40):24927–24933.doi:10.1074/jbc.271.40.24927.PMID 8798771.
  12. ^Youn HD, Chatila TA, Liu JO (Aug 2000)."Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis".The EMBO Journal.19 (16):4323–4331.doi:10.1093/emboj/19.16.4323.PMC 302027.PMID 10944115.
  13. ^Park SY, Shin HM, Han TH (Sep 2002). "Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter".Molecular Immunology.39 (1–2):25–30.doi:10.1016/s0161-5890(02)00055-x.PMID 12213324.
  14. ^Choi SJ, Park SY, Han TH (Jul 2001)."14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation".Nucleic Acids Research.29 (13):2836–2842.doi:10.1093/nar/29.13.2836.PMC 55772.PMID 11433030.

Further reading

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External links

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PDB gallery
  • 1c7u: Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide
    1c7u: Complex of the DNA binding core domain of the transcription factor MEF2A with a 20mer oligonucleotide
  • 1egw: CRYSTAL STRUCTURE OF MEF2A CORE BOUND TO DNA
    1egw: CRYSTAL STRUCTURE OF MEF2A CORE BOUND TO DNA
(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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