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MED16

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MED16
Identifiers
AliasesMED16, DRIP92, THRAP5, TRAP95, mediator complex subunit 16
External IDsOMIM:604062;MGI:2158394;HomoloGene:64602;GeneCards:MED16;OMA:MED16 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MED16
Genomic location for MED16
Band19p13.3Start867,630bp[1]
End893,218bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for MED16
Genomic location for MED16
Band10|10 C1Start79,730,542bp[2]
End79,744,757bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • right uterine tube

  • right lobe of liver

  • gastric mucosa

  • canal of the cervix

  • apex of heart

  • gonad

  • granulocyte

  • anterior pituitary

  • muscle of thigh
Top expressed in
  • seminiferous tubule

  • internal carotid artery

  • external carotid artery

  • spermatocyte

  • Rostral migratory stream

  • epithelium of stomach

  • dentate gyrus of hippocampal formation granule cell

  • tibiofemoral joint

  • molar

  • extraocular muscle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10025

216154

Ensembl

ENSG00000282092
ENSG00000175221

ENSMUSG00000013833

UniProt

Q9Y2X0

Q6PGF3

RefSeq (mRNA)

NM_005481

NM_001163276
NM_198107
NM_001359629

RefSeq (protein)

NP_005472

XP_006513550.1
XP_006513551.1

Location (UCSC)Chr 19: 0.87 – 0.89 MbChr 10: 79.73 – 79.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Mediator of RNA polymerase II transcription subunit 16 is anenzyme that in humans is encoded by theMED16gene.[5][6][7]


Interactions

[edit]

MED16 has been shown tointeract withThyroid hormone receptor alpha,[6]Estrogen receptor alpha[8] andCyclin-dependent kinase 8.[6][8]

References

[edit]
  1. ^abcENSG00000175221 GRCh38: Ensembl release 89: ENSG00000282092, ENSG00000175221 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000013833 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Naar AM, Erdjument-Bromage H, Tempst P, Freedman LP (Jun 1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex".Nature.398 (6730):824–8.Bibcode:1999Natur.398..824R.doi:10.1038/19783.PMID 10235266.S2CID 204992765.
  6. ^abcIto M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Apr 1999)."Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators".Mol Cell.3 (3):361–70.doi:10.1016/S1097-2765(00)80463-3.PMID 10198638.
  7. ^"Entrez Gene: THRAP5 thyroid hormone receptor associated protein 5".
  8. ^abKang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002)."The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro".Proc. Natl. Acad. Sci. U.S.A.99 (5). United States:2642–7.Bibcode:2002PNAS...99.2642K.doi:10.1073/pnas.261715899.ISSN 0027-8424.PMC 122401.PMID 11867769.

Further reading

[edit]

External links

[edit]


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