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MARK1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MARK1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2HAK,3OSE

Identifiers
AliasesMARK1, MARK, Par-1c, Par1c, microtubule affinity regulating kinase 1
External IDsOMIM:606511;MGI:2664902;HomoloGene:49552;GeneCards:MARK1;OMA:MARK1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MARK1
Genomic location for MARK1
Band1q41Start220,528,136bp[1]
End220,664,461bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for MARK1
Genomic location for MARK1
Band1|1 H5Start184,628,986bp[2]
End184,731,767bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • corpus epididymis

  • Pons

  • cerebellar vermis

  • Brodmann area 23

  • superior frontal gyrus

  • spinal ganglia

  • endothelial cell

  • primary visual cortex
Top expressed in
  • trigeminal ganglion

  • motor neuron

  • barrel cortex

  • substantia nigra

  • fossa

  • external carotid artery

  • condyle

  • internal carotid artery

  • tunica media of zone of aorta

  • ascending aorta
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4139

226778

Ensembl

ENSG00000116141

ENSMUSG00000026620

UniProt

Q9P0L2

Q8VHJ5

RefSeq (mRNA)

NM_001286124
NM_001286126
NM_001286128
NM_001286129
NM_018650

NM_145515
NM_001378876

RefSeq (protein)

NP_001273053
NP_001273055
NP_001273057
NP_001273058
NP_061120

NP_663490
NP_001365805

Location (UCSC)Chr 1: 220.53 – 220.66 MbChr 1: 184.63 – 184.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase MARK1 is anenzyme that in humans is encoded by theMARK1gene.[5][6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000116141Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000026620Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (May 1997)."MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption".Cell.89 (2):297–308.doi:10.1016/S0092-8674(00)80208-1.PMID 9108484.S2CID 15647848.
  6. ^"Entrez Gene: MARK1 MAP/microtubule affinity-regulating kinase 1".

Further reading

[edit]
PDB gallery
  • 2hak: Catalytic and ubiquitin-associated domains of MARK1/PAR-1
    2hak: Catalytic and ubiquitin-associated domains of MARK1/PAR-1
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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