Function

Clinical significance

Signaling pathways

Interactions

• DUSP3,^[10]
• DUSP6^[11]
• GTF2I,^[12]
• HDAC4,^[13]
• MAP2K1,^{[14][15][16][17]}
• MAP2K2,^[14][15][17]
• PTPN7,^[18][19][20]
• RPS6KA2,^[21][22] and
• SPIB.^[23]

References

1. ^^abcGRCh38: Ensembl release 89: ENSG00000102882 –Ensembl, May 2017
2. ^^abcGRCm38: Ensembl release 89: ENSMUSG00000063065 –Ensembl, May 2017
3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^Thomas, Gareth M.; Huganir, Richard L. (1 March 2004). "MAPK cascade signalling and synaptic plasticity".Nature Reviews Neuroscience.5 (3):173–183.doi:10.1038/nrn1346.ISSN 1471-003X.PMID 14976517.S2CID 205499891.
6. ^García F, Zalba G, Páez G, Encío I, de Miguel C (15 May 1998). "Molecular cloning and characterization of the human p44 mitogen-activated protein kinase gene".Genomics.50 (1):69–78.doi:10.1006/geno.1998.5315.PMID 9628824.
7. ^"Entrez Gene: MAPK3 mitogen-activated protein kinase 3".
8. ^Buggele WA, Johnson KE, Horvath CM (2012)."Influenza A virus infection of human respiratory cells induces primary microRNA expression".J. Biol. Chem.287 (37):31027–40.doi:10.1074/jbc.M112.387670.PMC 3438935.PMID 22822053.
9. ^Pal R, Bondar VV, Adamski CJ, Rodney GG, Sardiello M (2017)."Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis".Sci. Rep.7 (1): 4174.Bibcode:2017NatSR...7.4174P.doi:10.1038/s41598-017-04528-5.PMC 5482840.PMID 28646232.
10. ^Todd JL, Tanner KG, Denu JM (May 1999)."Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway".J. Biol. Chem.274 (19):13271–80.doi:10.1074/jbc.274.19.13271.PMID 10224087.
11. ^Muda M, Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S (April 1998)."The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity".J. Biol. Chem.273 (15):9323–9.doi:10.1074/jbc.273.15.9323.PMID 9535927.
12. ^Kim DW, Cochran BH (February 2000)."Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter".Mol. Cell. Biol.20 (4):1140–8.doi:10.1128/mcb.20.4.1140-1148.2000.PMC 85232.PMID 10648599.
13. ^Zhou X, Richon VM, Wang AH, Yang XJ, Rifkind RA, Marks PA (December 2000)."Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras".Proc. Natl. Acad. Sci. U.S.A.97 (26):14329–33.Bibcode:2000PNAS...9714329Z.doi:10.1073/pnas.250494697.PMC 18918.PMID 11114188.
14. ^^abMarti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J (January 1997)."Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells".J. Biol. Chem.272 (5):2620–8.doi:10.1074/jbc.272.5.2620.PMID 9006895.
15. ^^abButch ER, Guan KL (February 1996)."Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2".J. Biol. Chem.271 (8):4230–5.doi:10.1074/jbc.271.8.4230.PMID 8626767.
16. ^Elion EA (September 1998). "Routing MAP kinase cascades".Science.281 (5383):1625–6.doi:10.1126/science.281.5383.1625.PMID 9767029.S2CID 28868990.
17. ^^abZheng CF, Guan KL (November 1993)."Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases".J. Biol. Chem.268 (32):23933–9.doi:10.1016/S0021-9258(20)80474-8.PMID 8226933.
18. ^Pettiford SM, Herbst R (February 2000)."The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP".Oncogene.19 (7):858–69.doi:10.1038/sj.onc.1203408.PMID 10702794.
19. ^Saxena M, Williams S, Taskén K, Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase".Nat. Cell Biol.1 (5):305–11.doi:10.1038/13024.PMID 10559944.S2CID 40413956.
20. ^Saxena M, Williams S, Brockdorff J, Gilman J, Mustelin T (April 1999)."Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)".J. Biol. Chem.274 (17):11693–700.doi:10.1074/jbc.274.17.11693.PMID 10206983.
21. ^Roux PP, Richards SA, Blenis J (July 2003)."Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity".Mol. Cell. Biol.23 (14):4796–804.doi:10.1128/mcb.23.14.4796-4804.2003.PMC 162206.PMID 12832467.
22. ^Zhao Y, Bjorbaek C, Moller DE (November 1996)."Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases".J. Biol. Chem.271 (47):29773–9.doi:10.1074/jbc.271.47.29773.PMID 8939914.
23. ^Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors".Oncogene.12 (4):863–73.PMID 8632909.

Further reading

• Peruzzi F, Gordon J, Darbinian N, Amini S (2002). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway".J. Neurovirol. 8 Suppl 2 (2):91–6.doi:10.1080/13550280290167885.PMID 12491158.
• Meloche S, Pouysségur J (2007)."The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition".Oncogene.26 (22):3227–39.doi:10.1038/sj.onc.1210414.PMID 17496918.
• Ruscica M, Dozio E, Motta M, Magni P (2007),"Modulatory Actions of Neuropeptide y on Prostate Cancer Growth: Role of MAP Kinase/ERK 1/2 Activatio",Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation, Advances In Experimental Medicine And Biology, vol. 604, Springer, pp. 96–100,doi:10.1007/978-0-387-69116-9_7,ISBN 978-0-387-69114-5,PMID 17695723

External links