Mitogen-activated protein kinase 1 (MAPK 1), also known asERK2, is anenzyme that in humans is encoded by theMAPK1gene.[5]
The protein encoded by this gene is a member of theMAP kinase family. MAP kinases, also known asextracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such asproliferation,differentiation, transcription regulation and development. The activation of thiskinase requires itsphosphorylation by upstreamkinases. Upon activation, this kinase translocates to thenucleus of the stimulated cells, where itphosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in theUTRs, have been reported for this gene.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]
MAPK1 has been shown tointeract with:
Mutations in MAPK1 are implicated in many types of cancer.[45]