Protein-coding gene in the species Homo sapiens
Mannose-6-phosphate receptor binding protein 1 (M6PRBP1 ) is aprotein which in humans is encoded by theM6PRBP1 gene .[ 5] TIP47 .
Mannose 6-phosphate receptors (MPRs) deliverlysosomal hydrolase from theGolgi toendosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A ), a member of theRAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[ 6]
The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[ 7] lipid droplets .[ 8]
TIP47 belongs to theperipilin protein family and shares significant homology with the other genes of this family, includingperilipin andadipophilin .[ 9]
M6PRBP1 has been shown tointeract with bothMannose 6-phosphate receptors .[ 10] [ 11]
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