The settlement in theDuchy of Styria was first documented in 1227. The minnesingerUlrich von Liechtenstein in his 1265 poemFrauendienst mentionedMurzuslage, which he passed on his journey fromVenice to Vienna. In 1360 theHabsburg dukeRudolf IV confirmed the inhabitants' privilege ofiron production, competing with the town ofLeoben.
In 1854 theSemmering railway opened, by which theAustrian Southern Railway company provided direct access to Vienna, largely promoting the local economy. The Bleckmannsteel mill was founded in 1862, it is today part ofBöhler-Uddeholm. A railway museum exhibits a collection of steam locomotives, associated equipment and rolling stock.
In the late 19th century, the mountainous Semmering area was the site of the firstalpine skiing attempts in Central Europe, which made it one of the oldest ski resorts of Austria, documented by the world's largestskiing and winter sports museum. Mürzzuschlag receivedtown privileges in 1923.