The drug has been reported to have mild and relatively short-lasting LSD-like effects in humans at anoral dose of 800μg equivalent to one-tenth this amount of LSD (i.e., 80μg).[1][5][6] Based on different clinical studies, it is estimated to be 5 to 10% aspotent as LSD in humans.[5][7] Itsduration was shorter than that of LSD, lasting around 5hours as opposed to 7hours in the case of LSD.[6] The drug producednausea at small doses in humans, which was dose-limiting in terms of evaluating its effects.[8]
^abcdParrish JC (30 October 2007)."Toward a molecular understanding of hallucinogen action".Purdue e-Pubs.Figure A.1 The series of amide substituted LSD derivatives used in this study. [...] LA-Pyr [...] Table A.1 Results of competition binding experiments and IP accumulation assays for the series of ergolines illustrated in Figure A.1. [...] LA-Pyr [...]
^abcNichols DE (2012)."Structure–activity relationships of serotonin 5-HT2A agonists".Wiley Interdisciplinary Reviews: Membrane Transport and Signaling.1 (5):559–579.doi:10.1002/wmts.42.ISSN2190-460X.TABLE 1 5-HT2A Receptor Affinity and Functional Effects of Selected Lysergamides1 [...] 1 Data from Parrish.42. [...] 42. Parrish JC. Toward a molecular understanding of hallucinogen action. 2006. Purdue University.
^abDunn WJ, Bederka JP (February 1974). "The role of hydrophobicity in the antiserotonin activity of LSD analogs".Research Communications in Chemical Pathology and Pharmacology.7 (2):275–285.PMID4818374.
^abcFanchamps A (1978)."Some Compounds With Hallucinogenic Activity".Ergot Alkaloids and Related Compounds. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 567–614.doi:10.1007/978-3-642-66775-6_8.ISBN978-3-642-66777-0. Retrieved3 June 2025.Lysergic acid pyrrolidide (LPD 824, No. 73 f) exhibits a modest LSD-like psychic effect (MURPHREE et a!., 1958), which ABRAMSON (1959) quantifies at 5% and ISBELL et a!. (1959 a) at 10% of the LSD-activity. As a serotonin-inhibitor, it shows 5% of the LSD-potency (CERLETTI and DOEPFNER, 1958a). Its dual action on the body temperature of the rat is identical to that of LSD (CERLETTI, 1956); as a pyretogenic in the rabbit, it exhibits 10% of the LSD potency (Sandoz Res. Lab., 1958).
^abIsbell H, Miner EJ, Logan CR (1959). "Relationships of psychotomimetic to anti-serotonin potencies of congeners of lysergic acid diethylamide (LSD-25)".Psychopharmacologia.1:20–28.doi:10.1007/BF00408108.PMID14405872.
^abHoffer A (1965). "D-Lysergic acid diethylamide (LSD): A review of its present status".Clinical Pharmacology and Therapeutics.6 (2):183–255.doi:10.1002/cpt196562183.PMID14288188.
^abCerletti A (1956)."Lysergic Acid Diethylamide (LSD) and Related Compounds". In Abramson HA (ed.).Neuropharmacology: Transactions of the 2nd Conference, May 25-27, 1955, Princeton, N.J. New York: Josiah Macy. pp. 9–84.Cerletti: LPD-824 is chemically related to LSD. It is the pyrrolidid of lysergic acid, having the diethylamino group closed to a pyrrolidine nucleus (Figure 7). When this substance was tested in man, doses up to 1/2 μg./kg, were given intravenously without producing any LSD-like symptoms. Pharmacologically LPD is a very strong hypotensive agent. In animals 10 μg./kg. produces hypotension, both in cats and in dogs. As already said, in human subjects it had no psychic effect, but produced nausea in such small doses that a hypotensive effect could not be achieved.
^Oberlender R, Pfaff RC, Johnson MP, Huang XM, Nichols DE (January 1992). "Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane".Journal of Medicinal Chemistry.35 (2):203–211.doi:10.1021/jm00080a001.PMID1732537.The pyrrolidyl amide (4) was also included in the behavioral pharmacology part of this study, [...] Table I. Potency of Lysergic Acid Amides in 1-Trained Rats [...]
^Oberlender RA (May 1989)."Stereoselective aspects of hallucinogenic drug action and drug discrimination studies of entactogens".Purdue e-Pubs. Purdue University.The results of the drug discrimination testing are given in Table 3. The experimental data can be found in Table 15 in appendix B. The four isomers of 17, and the pyrrolidide 5, completely substituted for LSD. [...] Table 3. Potency of lysergic acid amides in LSD-trained rats. [...]
^Abramson HA (July 1960). "Lysergic acid diethylamide (LSD-25). XXXI. Comparison by questionnaire of psychotomimetic activity of congeners on normal subjects and drug addicts".The Journal of Mental Science.106 (444):1120–1123.doi:10.1192/bjp.106.444.1120.PMID13681136.
