Lynne Maquat | |
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| Born | Lynne Elizabeth Maquat |
| Nationality | American |
| Alma mater | University of Wisconsin–Madison University of Connecticut |
| Known for | RNA biology in human diseases |
| Awards | Albany Medical Center Prize in Medicine and Biomedical Research (2024) Dr. Paul Janssen Award for Biomedical Research (2024) Gruber Prize in Genetics (2023) Wolf Prize in Medicine (2021) FASEB Excellence in Science Award (2018) Wiley Prize (2018) Gairdner Foundation International Award (2015) William C. Rose Award (2014) Member of the National Academy of Sciences (2011) |
| Scientific career | |
| Fields | Biochemistry Molecular biology Cell biology |
| Institutions | University of Rochester |
| Doctoral advisor | William S. Reznikoff[citation needed] |
| Website | www |
Lynne Elizabeth Maquat is an American biochemist and molecular biologist whose research focuses on the cellular mechanisms of human disease. She is known for her work in describing the process ofnonsense-mediated decay. She is an elected member of theAmerican Academy of Arts and Sciences,[1] theNational Academy of Sciences[2] and theNational Academy of Medicine.[3] She currently holds the J. Lowell Orbison Endowed Chair and is a professor of biochemistry and biophysics, pediatrics and oncology at theUniversity of Rochester Medical Center.[4]
Maquat graduatedmagna cum laude with aBachelor of Science degree in biology from theUniversity of Connecticut in 1974. She received her PhD in biochemistry from theUniversity of Wisconsin-Madison in 1979.[5]
Maquat didpostdoctoral research at the McArdle Laboratory for Cancer Research in Madison, Wisconsin. She then had a brief stint atRoswell Park Comprehensive Cancer Center inBuffalo, New York before settling at the University of Rochester in Rochester, New York, where she now holds an endowed chair. Her research is focused onmRNA decay and the molecular basis of human disease. Her research Specifically, she was the first to describenonsense-mediated mRNA decay, work that enabled the discovery of theexon junction complex as a critical quality-control mechanism in the cell. She also describedStaufen-mediated mRNA decay, a competitive process to NMD, andmicroRNA degradation. Her research began withbeta thalassemia as a model and expanded to otherhemoglobinopathies. She has also studied cell death inbreast cancer cells exposed to chemotherapy, and cellular differentiation in muscle cells. Maquat also founded the Graduate Women in Science program at the University of Rochester Medical School, which provides mentoring and support to women seeking graduate education in the sciences.[6][7][8]
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