Longer than typical lifespan, especially of humans
"Human longevity" redirects here. For the company, seeHuman Longevity.
Comparison of male and female life expectancy at birth for countries and territories as defined byWHO for 2019. The green dotted line corresponds to equal female and male life expectancy. Open the originalsvg-image in a separate window and hover over a bubble to see more detailed information. The square of the bubbles is proportional to the country's population based on estimation of theUN.
Longevity may refer to especially long-lived members of a population, whereaslife expectancy is definedstatistically as the average number of years remaining at a given age. For example, a population's life expectancy at birth is the same as the average age at death for all people born in the same year (in the case ofcohorts).
Longevity studies may involve putative methods to extend life. Longevity has been a topic not only for the scientific community but also for writers oftravel,science fiction, andutopian novels. The legendary fountain of youth appeared in the work of the Ancient Greek historianHerodotus.
There are difficulties in authenticating the longest humanlife span, owing to inaccurate or incomplete birth statistics. Fiction, legend, and folklore have proposed or claimed life spans in the past or future vastly longer than those verified by modern standards, andlongevity narratives and unverifiedlongevity claims frequently speak of their existence in the present.
Eilif Philipsen (21 July 1682 – 20 June 1785, 102 years, 333 days): first person to reach the age of 100 (on 21 July 1782) and whose age could be validated.[7][8]
Geert Adriaans Boomgaard (1788–1899, 110 years, 135 days): first person to reach the age of 110 (on September 21, 1898) and whose age could be validated.
Margaret Ann Neve, (18 May 1792 – 4 April 1903, 110 years, 346 days) the first validated female supercentenarian (on 18 May 1902).
Jeanne Calment (1875–1997, 122 years, 164 days): the oldest person in history whose age has been verified by modern documentation.[note 1] This defines the modern humanlife span, which is set by the oldest documented individual who ever lived.
Sarah Knauss (1880–1999, 119 years, 97 days): the third oldest documented person in modern times and the oldest American.
Jiroemon Kimura (1897–2013, 116 years, 54 days): the oldest man in history whose age has been verified by modern documentation.
Kane Tanaka (1903–2022, 119 years, 107 days): the second oldest documented person in modern times and the oldest Japanese.
Twin studies have estimated that approximately 20-30% of the variation in human lifespan can be related togenetics, with the rest due to individual behaviors andenvironmental factors which can be modified.[11] Although over 200 gene variants have been associated with longevity according to a US-Belgian-UK research database of human genetic variants[12] these explain only a small fraction of the heritability.[13]
Lymphoblastoid cell lines established from blood samples ofcentenarians have significantly higher activity of the DNA repair protein PARP (Poly ADP ribose polymerase) than cell lines from younger (20 to 70 year old) individuals.[14] The lymphocytic cells of centenarians have characteristics typical of cells from young people, both in their capability of priming the mechanism of repair afterH2O2 sublethaloxidative DNA damage and in their PARP gene expression.[15] These findings suggest that elevated PARP gene expression contributes to the longevity of centenarians, consistent with theDNA damage theory of aging.[16]
"Healthspan, parental lifespan, and longevity are highly genetically correlated."[17]
In July2020, scientists used publicbiological data on 1.75 m people with known lifespans overall and identified 10genomic loci which appear to intrinsically influencehealthspan, lifespan, and longevity – of which half have not been reported previously atgenome-wide significance and most being associated withcardiovascular disease – and identifiedhaem metabolism as a promising candidate for further research within the field. Their study suggests that high levels of iron in the blood likely reduce, and genes involved in metabolising iron likely increase healthy years of life in humans.[18][17]
Longevity is a highly plastic trait, and traits that influence its components respond to physical (static) environments and to wide-ranging life-style changes: physical exercise, dietary habits, living conditions, and pharmaceutical as well as nutritional interventions.[19][20][21] A 2012 study found that even modest amounts of leisure time physical exercise can extend life expectancy by as much as 4.5 years.[22]
As of 2021, there is noclinical evidence that any dietary practice contributes to human longevity.[23] Although health can be influenced by diet, including the type of foods consumed, the amount of calories ingested, and the duration and frequency of fasting periods,[24] there is no good clinical evidence that fasting promotes longevity in humans, as of 2021[update].[23][25][26]
Calorie restriction is a widely researched intervention to assess effects on aging, defined as a sustained reduction in dietary energy intake compared to the energy required for weight maintenance.[23][25] To ensure metabolichomeostasis, the diet during calorie restriction must provide sufficient energy, micronutrients, and fiber.[25] Some studies on rhesus monkeys showed that restricting calorie intake resulted in lifespan extension, while other animals studies did not detect a significant change.[23][27] According to preliminary research in humans, there is little evidence that calorie restriction affects lifespan.[23][25] There is a link betweendiet and obesity and consequentobesity-associated morbidity.
Four well-studiedbiological pathways that are known to regulate aging, and whose modulation has been shown to influence longevity areInsulin/IGF-1, mechanistic target of rapamycin (mTOR), AMP-activating protein kinase (AMPK), andSirtuin pathways.[28][29]
Post-COVID life expectancy in the US, UK, Netherlands, and Austria
In preindustrial times, deaths at young and middle age were more common than they are today. This is not due to genetics, but because of environmental factors such as disease, accidents, and malnutrition, especially since the former were not generally treatable with pre-20th-century medicine. Deaths from childbirth were common for women, and many children did not live past infancy. In addition, most people who did attain old age were likely to die quickly from the above-mentioned untreatable health problems. Despite this, there are several examples of pre-20th-century individuals attaining lifespans of 85 years or greater, includingJohn Adams,Cato the Elder,Thomas Hobbes,Christopher Polhem, andMichelangelo. This was also true for poorer people likepeasants orlaborers.[citation needed]Genealogists will almost certainly find ancestors living to their 70s, 80s and even 90s several hundred years ago.
For example, an 1871 census in the UK (the first of its kind, but personal data from other censuses dates back to 1841 and numerical data back to 1801) found the average male life expectancy as being 44, but if infant mortality is subtracted, males who lived to adulthood averaged 75 years. The present life expectancy in the UK is 77 years for males and 81 for females, while the United States averages 74 for males and 80 for females.
Studies have shown that black American males have the shortest lifespans of any group of people in the US, averaging only 69 years (Asian-American females average the longest).[30] This reflects overall poorer health and greater prevalence of heart disease, obesity, diabetes, and cancer among black American men.
Women normally outlive men. Theories for this include smaller bodies that place lesser strain on the heart (women have lower rates ofcardiovascular disease) and a reduced tendency to engage in physically dangerous activities.[31] Conversely, women are more likely to participate in health-promoting activities.[32] TheX chromosome also contains more genes related to the immune system, and women tend to mount a stronger immune response to pathogens than men.[33] However, the idea that men have weaker immune systems due to the supposed immuno-suppressive actions of testosterone is unfounded.[34]
There is debate as to whether the pursuit of longevity is a worthwhile health care goal. BioethicistEzekiel Emanuel, who is also one of the architects ofObamaCare, has argued that the pursuit of longevity via thecompression of morbidity explanation is a "fantasy" and that longevity past age 75 should not be considered an end in itself.[35] This has been challenged by neurosurgeonMiguel Faria, who states that life can be worthwhile in healthy old age, that the compression of morbidity is a real phenomenon, and that longevity should be pursued in association with quality of life.[36] Faria has discussed how longevity in association with leading healthy lifestyles can lead to the postponement ofsenescence as well as happiness and wisdom in old age.[37]
Most biological organisms have a naturally limited longevity due toaging, unlike a rare few that are consideredbiologically immortal.
Given that different species of animals and plants have different potentials for longevity, the disrepair accumulation theory of aging tries to explain how the potential for longevity of an organism is sometimes positively correlated to its structural complexity. It suggests that while biological complexity increases individual lifespan, it is counteracted in nature since the survivability of the overall species may be hindered when it results in a prolongeddevelopment process, which is an evolutionarily vulnerable state.[38]
According to theantagonistic pleiotropy hypothesis, one of the reasons biological immortality is so rare is that certain categories ofgene expression that are beneficial in youth become deleterious at an older age.
Longevity myths are traditions about long-lived people (generallysupercentenarians), either as individuals or groups of people, and practices that have been believed to confer longevity, but for which scientific evidence does not support the ages claimed or the reasons for the claims.[39][40] A comparison and contrast of "longevity in antiquity" (such as theSumerian King List, thegenealogies of Genesis, and the PersianShahnameh) with "longevity in historical times" (common-era cases through twentieth-century news reports) is elaborated in detail inLucian Boia's 2004 bookForever Young: A Cultural History of Longevity from Antiquity to the Present and other sources.[41]
After the death ofJuan Ponce de León,Gonzalo Fernández de Oviedo y Valdés wrote inHistoria General y Natural de las Indias (1535) that Ponce de León was looking for the waters ofBimini to cure his aging.[42] Traditions that have been believed to confer greater human longevity also includealchemy,[43] such as that attributed toNicolas Flamel. In the modern era, theOkinawa diet has some reputation of linkage to exceptionally high ages.[44]
Longevity claims may be subcategorized into four groups: "In late life, very old people often tend to advance their ages at the rate of about 17 years per decade .... Several celebrated super-centenarians (over 110 years) are believed to have been double lives (father and son, relations with the same names or successive bearers of a title) .... A number of instances have been commercially sponsored, while a fourth category of recent claims are those made for political ends ...."[45] The estimate of 17 years per decade was corroborated by the 1901 and 1911 British censuses.[45]Time magazine considered that, by the Soviet Union, longevity had been elevated to a state-supported "Methuselah cult".[46]
Longevity in other animals can shed light on the determinants of life expectancy in humans, especially when found in relatedmammals. However, important contributions to longevity research have been made by research in other species, ranging fromyeast toflies toworms. In fact, some closely related species of vertebrates can have dramatically different life expectancies, demonstrating that relatively small genetic changes can have a dramatic impact on aging. For instance, Pacific Ocean rockfishes have widely varying lifespans. The speciesSebastes minor lives a mere 11 years while its cousinSebastes aleutianus can live for more than 2 centuries.[48] Similarly, achameleon,Furcifer labordi, is the current record holder forshortest lifespan amongtetrapods, with only 4–5 months to live.[49] By contrast, some of its relatives, such asFurcifer pardalis, have been found to live up to 6 years.[50]
Honey bees (Apis mellifera) are eusocial insects that display dramatic caste-specific differences in longevity. Queen bees live for an average of 1-2 years, compared to workers who live on average 15-38 days in summer and 150-200 days in winter.[57] Worker honey bees with high amounts of flight experience exhibit increasedDNA damage in flight muscle, as measured by elevated8-Oxo-2'-deoxyguanosine, compared to bees with less flight experience.[58] This increased DNA damage is likely due to an imbalance of pro- and anti-oxidants during flight-associatedoxidative stress. Flight induced oxidative DNA damage appears to hasten senescence and reduce longevity inA. mellifera.[58]
Thequahog clam (Arctica islandica) is exceptionally long-lived, with a maximum recorded age of 507 years, the longest of any animal.[60] Other clams of the species have been recorded as living up to 374 years.[61]
Lamellibrachia luymesi, a deep-sea cold-seep tubeworm, is estimated to reach ages of over 250 years based on a model of its growth rates.[62]
Abowhead whale killed in a hunt was found to be approximately 211 years old (possibly up to 245 years old), the longest-lived mammal known.[63]
Possibly 250-million year-old bacteria,Bacillus permians, were revived from stasis after being found in sodium chloride crystals in a cavern in New Mexico.[64][65]
^Disputed. In 2018 it was alleged that Calment actually died in 1934, and her daughter Yvonne then usurped her mother's identity. Seehere for details.[9]
^Thatcher AR (2010). "The growth of high ages in England and Wales, 1635-2106".Supercentenarians. Demographic Research Monographs. Springer Berlin Heidelberg. pp. 191–201.doi:10.1007/978-3-642-11520-2_11.ISBN9783642115196.
^vB Hjelmborg J, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, et al. (April 2006). "Genetic influence on human lifespan and longevity".Human Genetics.119 (3):312–321.doi:10.1007/s00439-006-0144-y.PMID16463022.S2CID8470835.
^Budovsky A, Craig T, Wang J, Tacutu R, Csordas A, Lourenço J, et al. (October 2013). "LongevityMap: a database of human genetic variants associated with longevity".Trends in Genetics.29 (10):559–560.doi:10.1016/j.tig.2013.08.003.PMID23998809.
^Muiras ML, Müller M, Schächter F, Bürkle A (April 1998). "Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians".Journal of Molecular Medicine.76 (5):346–354.doi:10.1007/s001090050226.PMID9587069.S2CID24616650.
^Chevanne M, Calia C, Zampieri M, Cecchinelli B, Caldini R, Monti D, et al. (June 2007). "Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians".Rejuvenation Research.10 (2):191–204.doi:10.1089/rej.2006.0514.PMID17518695.
^Dato S, Rose G, Crocco P, Monti D, Garagnani P, Franceschi C, Passarino G (July 2017). "The genetics of human longevity: an intricacy of genes, environment, culture and microbiome".Mechanisms of Ageing and Development.165 (Pt B):147–155.doi:10.1016/j.mad.2017.03.011.PMID28390822.S2CID13654470.
^Keaten J (17 October 2012)."Health in America Today"(PDF).Measure of America.Archived(PDF) from the original on 3 April 2012. Retrieved17 October 2012.
^Wang J, Michelitsch T, Wunderlin A, Mahadeva R (2009). "Aging as a consequence of Misrepair –a novel theory of aging".arXiv:0904.0575 [q-bio.TO].
^Ni M (2006).Secrets of Longevity. Chronicle Books. p. 101.ISBN978-0-8118-4949-4.Chuan xiong ... has long been a key herb in the longevity tradition of China, prized for its powers to boost the immune system, activate blood circulation, and relieve pain.
^Fulder S (1983).An End to Ageing: Remedies for Life. Destiny Books. p. 27.ISBN978-0-89281-044-4.Taoist devotion to immortality is important to us for two reasons. The techniques may be of considerable value to our goal of a healthy old age, if we can understand and adapt them. Secondly, the Taoist longevity tradition has brought us many interesting remedies.
^Vallin J, Meslé F (February 2001)."Living Beyond the Age of 100"(PDF).Bulletin Mensuel d'Information de l'Institut National d'Études Démographiques: Population & Sociétés (365). Institut National d'Études Démographiques. Archived fromthe original(PDF) on 1 September 2012.
^Fernández de Oviedo, Gonzalo.Historia General y Natural de las Indias, book 16, chapter XI.
^Ripley Enterprises, Inc. (September 1969).Ripley's Believe It or Not! 15th Series. New York City:Pocket Books. pp. 112, 84, 56.The Old Man of the Sea / Yaupa / a native of Futuna, one of the New Hebrides Islands / regularly worked his own farm at the age of 130 / He died in 1899 of measles — a children's disease ... Horoz Ali, the last Turkish gatekeeper of Nicosia, Cyprus, lived to the age of 120 ... Francisco Huppazoli (1587–1702) of Casale, Italy, lived 114 years without a day's illness and had 4 children by his 5th wife — whom he married at the age of 98
^Stark G, Tamar K, Itescu Y, Feldman A, Meiri S (2018-10-26). "Cold and isolated ectotherms: drivers of reptilian longevity".Biological Journal of the Linnean Society.125 (4):730–740.doi:10.1093/biolinnean/bly153.ISSN0024-4066.
^abMargotta JW, Roberts SP, Elekonich MM (July 2018). "Effects of flight activity and age on oxidative damage in the honey bee,Apis mellifera".J Exp Biol.221 (Pt 14).doi:10.1242/jeb.183228.PMID29724776.
^Haston S, Pozzi S, Gonzalez-Meljem JM (2020), Gomez-Verjan JC, Rivero-Segura NA (eds.), "Applications of CRISPR-Cas in Ageing Research",Clinical Genetics and Genomics of Aging, Cham: Springer, pp. 213–230,doi:10.1007/978-3-030-40955-5_11,ISBN978-3-030-40955-5,S2CID218805944
Carey JR, Judge DS (2000). "Longevity records: Life Spans of Mammals, Birds, Amphibians, reptiles, and Fish.".Odense Monographs on Population Aging. Vol. 8. Odense University Press.ISBN87-7838-539-3.OCLC1319408379.
Gavrilova N, Gavrilov LA (2008). "Can exceptional longevity be predicted".Contingencies (Journal of the American Academy of Actuaries):82–8.
Gavrilova NS, Gavrilov LA (January 2007). "Search for predictors of exceptional human longevity: using computerized genealogies and internet resources for human longevity studies".North American Actuarial Journal.11 (1):49–67.doi:10.1080/10920277.2007.10597437.S2CID10996768.
Gavrilova NS, Gavrilov LA (2005). "Human longevity and reproduction: An evolutionary perspective.". In Voland E, Chasiotis A, Schiefenhoevel W (eds.).Grandmotherhood - The Evolutionary Significance of the Second Half of Female Life. New Brunswick, NJ: Rutgers University Press. pp. 59–80.ISBN978-0-8135-3609-5.OCLC1319331273.
Global Agewatch's country report cards have the most up-to-date, internationally comparable statistics on population ageing and life expectancy from 195 countries.
Media related toLongevity at Wikimedia Commons
