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| Trade names | Helleva |
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| Routes of administration | By mouth |
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| Formula | C23H32N6O5S |
| Molar mass | 504.61 g·mol−1 |
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Lodenafil (also known ashydroxyhomosildenafil, trade nameHelleva) is a drug belonging to a class of drugs calledPDE5 inhibitor, which many other erectile dysfunction drugs such assildenafil,tadalafil, andvardenafil also belong to. Likeudenafil andavanafil it belongs to a new generation of PDE5 inhibitors.
Lodenafil is formulated as aprodrug in the form of thecarbonate esterdimer,lodenafil carbonate, which breaks down in the body to form two molecules of the active drug lodenafil. This formulation has higher oralbioavailability than the parent drug.[1]
It is manufactured byCristália Produtos Químicos e Farmacêuticos inBrazil and sold there under the brand-name Helleva.[2]
It has undergone Phase III clinical trials,[3][4] but is not yet approved for use in theUnited States by theU.S. Food and Drug Administration.
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