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Locicortolone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Locicortolone
Clinical data
Other namesLocicortone; RU-24476; 9α,11β-Dichloro-21-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
Drug classCorticosteroid;Glucocorticoid
Identifiers
  • (8S,9R,10S,11S,13S,14S,16R,17S)-9,11-Dichloro-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H28Cl2O3
Molar mass411.36 g·mol−1
3D model (JSmol)
  • C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)Cl)Cl)C
  • InChI=1S/C22H28Cl2O3/c1-12-8-16-15-5-4-13-9-14(26)6-7-21(13,3)22(15,24)18(23)10-20(16,2)19(12)17(27)11-25/h6-7,9,12,15-16,18-19,25H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
  • Key:FKRMBGXNTOTQDI-IIEHVVJPSA-N

Locicortolone (developmental code nameRU-24476), orlocicortone, is asyntheticglucocorticoidcorticosteroid which was never marketed.[1][2]

References

[edit]
  1. ^Negwer M, Scharnow HG (2001).Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 3795.ISBN 978-3-527-30247-5.
  2. ^"The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances"(PDF). World Health Organization. 2013. Archived fromthe original(PDF) on 22 October 2014.


GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others


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