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List of opioids

From Wikipedia, the free encyclopedia

Opium poppy (Papaver somniferum) flower

This is alist ofopioids,opioid antagonists andinverse agonists.

Opium and poppy straw derivatives

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Seedhead of opium poppy with white latex

Crude opiate extracts whole opium products

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Natural opiates

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Opium alkaloids

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See also:Components of opium
Structures
Morphides
Chemical structure of codeine.CodeineChemical structure of morphine.MorphineChemical structure of oripavine.OripavineChemical structure of pseudomorphine.PseudomorphineChemical structure of thebaine.Thebaine

Alkaloid salts mixtures

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Semisynthetics including Bentley compounds

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Morphine family

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Structures of Morphine family
Morphine family
Chemical structure of 14-hydroxymorphine.14-HydroxymorphineChemical structure of 2,4-dinitrophenylmorphine.2,4-DinitrophenylmorphineChemical structure of 6-methyldihydromorphine.6-MethyldihydromorphineChemical structure of 6-methylenedihydrodesoxymorphine.6-MethylenedihydrodesoxymorphineChemical structure of 6-acetyldihydromorphine hydrochloride.6-Acetyldihydromorphine hydrochloride
Chemical structure of azidomorphine.AzidomorphineChemical structure of chlornaltrexamine.ChlornaltrexamineChemical structure of chloroxymorphamine.ChloroxymorphamineChemical structure of desomorphine.Desomorphine
(Dihydrodesoxymorphine)		Chemical structure of dihydromorphine.Dihydromorphine
Chemical structure of ethyldihydromorphine.EthyldihydromorphineChemical structure of hydromorphinol.HydromorphinolChemical structure of methyldesorphine.MethyldesorphineChemical structure of N-phenethylnormorphine.N-PhenethylnormorphineChemical structure of 6-nicotinoyldihydromorphine.6-nicotinoyldihydromorphine
Chemical structure of RAM-378.RAM-378

3,6-diesters of morphine

[edit]
Structures
3,6-diesters of morphine
Chemical structure of acetylpropionylmorphine.Acetylpropionylmorphine3,6-DibutanoylmorphineChemical structure of diacetyldihydromorphine.Diacetyldihydromorphine
(dihydroheroin, acetylmorphinol)
Chemical structure of dibutyrylmorphine.DibutyrylmorphineChemical structure of dibenzoylmorphine.DibenzoylmorphineChemical structure of diformylmorphine.Diformylmorphine
Chemical structure of dipropanoylmorphine.DipropanoylmorphineChemical structure of heroin.Heroin
(diacetylmorphine)		Chemical structure of nicomorphine.Nicomorphine

Codeine-dionine family

[edit]
Structures
Codeine-dionine family
Chemical structure of 6-monoacetylcodeine.6-MonoacetylcodeineChemical structure of benzylmorphine.BenzylmorphineChemical structure of codeine methylbromide.Codeine methylbromideChemical structure of desocodeine.DesocodeineChemical structure of dimethylmorphine.Dimethylmorphine
(6-O-Methylcodeine)
Chemical structure of ethyldihydromorphine.EthyldihydromorphineChemical structure of methyldihydromorphine.Methyldihydromorphine
(dihydroheterocodeine)		Chemical structure of ethylmorphine.EthylmorphineChemical structure of heterocodeine.HeterocodeineChemical structure of isocodeine.Isocodeine
Chemical structure of pholcodine.PholcodineChemical structure of myrophine.MyrophineChemical structure of transisocodeine.Transisocodeine

Morphinones and morphols

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Structures
Morphinones and morphols
Chemical structure of 14-cinnamoyloxycodeinone.14-CinnamoyloxycodeinoneChemical structure of 14-ethoxymetopon.14-EthoxymetoponChemical structure of 14-methoxymetopon.14-MethoxymetoponChemical structure of 14-phenylpropoxymetopon.14-PhenylpropoxymetoponChemical structure of 7-spiroindanyloxymorphone.7-Spiroindanyloxymorphone
Chemical structure of 8,14-dihydroxydihydromorphinone.8,14-DihydroxydihydromorphinoneChemical structure of acetylcodone.AcetylcodoneChemical structure of acetylmorphone.AcetylmorphoneChemical structure of α-hydrocodol (dihydrocodeine).α-hydrocodol
(Dihydrocodeine)		Image not available.Bromoisopropropyldihydromorphinone
Chemical structure of codeinone.CodeinoneChemical structure of codorphone.CodorphoneChemical structure of codeine phosphate. Codol
(Codeine Phosphate)		Chemical structure of codoxime.CodoximeChemical structure of IBNtxA.IBNtxA
Chemical structure of thebacon.ThebaconChemical structure of hydrocodone.HydrocodoneChemical structure of hydromorphone.HydromorphoneChemical structure of hydroxycodeine.HydroxycodeineChemical structure of metopon.Metopon
(methyldihydromorphinone)
Chemical structure of morphenol.MorphenolChemical structure of morphinone.MorphinoneChemical structure of morphol.MorpholChemical structure of N-phenethyl-14-ethoxymetopon.N-Phenethyl-14-ethoxymetoponChemical structure of oxycodone.Oxycodone
Chemical structure of oxymorphol.OxymorpholChemical structure of oxymorphone.OxymorphoneChemical structure of pentamorphone.PentamorphoneChemical structure of semorphone.Semorphone

Morphides

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Structures
Morphides
Chemical structure of alpha-chlorocodide.α-chlorocodideChemical structure of beta-chlorocodide.β-chlorocodideChemical structure of bromomorphide.Bromomorphide
Chemical structure of chlorodihydrocodide.Chlorodihydrocodide.Chemical structure of chloromorphide.ChloromorphideChemical structure of codide.Codide

Dihydrocodeine series

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Structures
Morphides
Chemical structure of 14-hydroxydihydrocodeine.14-HydroxydihydrocodeineChemical structure of acetyldihydrocodeine.AcetyldihydrocodeineChemical structure of dihydrocodeine.DihydrocodeineChemical structure of dihydrodesoxycodeine.Dihydrodesoxycodeine
Chemical structure of dihydroisocodeine.DihydroisocodeineChemical structure of nicocodeine.NicocodeineChemical structure of nicodicodeine.Nicodicodeine

Nitrogen morphine derivatives

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Structures
Morphides
Chemical structure of 1-nitrocodeine.1-NitrocodeineChemical structure of codeine-N-oxide.Codeine-N-oxideChemical structure of morphine-N-oxide.Morphine-N-oxide

Hydrazones

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Structures
Hydrazones
Chemical structure of oxymorphazone.Oxymorphazone

Halogenated morphine derivatives

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Structures
Other open chain opioids
Chemical structure of 1-bromocodeine.

1-Bromocodeine

Chemical structure of 1-chlorocodeine.

1-Chlorocodeine

General structure of 1-iodomorphine.

1-Iodomorphine

Active opiate metabolites

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Structures
Active opiate metabolites
Chemical structure of codeine-N-oxide.Codeine-N-oxideChemical structure of heroin-7,8-oxide.Heroin-7,8-oxideChemical structure of morphine-6-glucuronide.Morphine-6-glucuronideGeneral structure of 6-monoacetylmorphine.6-Monoacetylmorphine
Chemical structure of morphine-N-oxide.Morphine-N-oxideChemical structure of naltrexol.NaltrexolChemical structure of norcodeine.NorcodeineGeneral structure of normorphine.Normorphine

Morphinans

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Levomethorphan

Morphinan series

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Structures
Other morphinans
Chemical structure of 4-chlorophenylpyridomorphinan4-chlorophenylpyridomorphinanChemical structure of cyclorphan.CyclorphanChemical structure of dextrallorphan.DextrallorphanChemical structure of levargorphanLevargorphanChemical structure of levophenacylmorphan.Levophenacylmorphan
Chemical structure of levomethorphanLevomethorphanChemical structure of norlevorphanol.NorlevorphanolChemical structure of N-methylmorphinan.N-MethylmorphinanChemical structure of oxilorphan.OxilorphanChemical structure of phenomorphan.Phenomorphan
Chemical structure of dextromethorphan.DextromethorphanChemical structure of Levomethorphan.levomethorphanChemical structure of morphanol.MorphanolChemical structure of Ro4-1539.Ro4-1539Chemical structure of stephodeline.StephodelineChemical structure of xorphanol.Xorphanol

Others

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Structures
Other Morphinans
Chemical structure of 1-nitroaknadinine1-NitroaknadinineChemical structure of 14-episinomenine.14-episinomenineChemical structure of 5,6-dihydronorsalutaridine.5,6-DihydronorsalutaridineChemical structure of 6-keto-nalbuphine6-Keto NalbuphineChemical structure of aknadinine.Aknadinine
Chemical structure of butorphanolButorphanolChemical structure of cephakicine.CephakicineChemical structure of cephasamine.CephasamineChemical structure of cyprodime.CyprodimeChemical structure of drotebanol.Drotebanol
Chemical structure of fenfangjine G.Fenfangjine GChemical structure of nalbuphine.NalbuphineChemical structure of sinococuline.SinococulineChemical structure of sinomenine.SinomenineChemical structure of tannagine.Tannagine

Benzomorphans

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Structures
Benzomorphans
Chemical structure of 5,9 alpha-diethyl-2-hydroxybenzomorphan.5,9 alpha-diethyl-2-hydroxybenzomorphan
(5,9-DEHB)		Chemical structure of 8-Carboxamidocyclazocine.8-CarboxamidocyclazocineGeneral structure of alazocine.AlazocineChemical structure of anazocine.AnazocineChemical structure of bremazocine.Bremazocine
Chemical structure of butinazocine.ButinazocineChemical structure of carbazocine.CarbazocineChemical structure of cogazocine.CogazocineChemical structure of cyclazocine.CyclazocineChemical structure of dezocine.Dezocine
Chemical structure of eptazocine.EptazocineChemical structure of etazocine.EtazocineChemical structure of ethylketocyclazocine.EthylketocyclazocineChemical structure of fedotozine.FedotozineChemical structure of fluorophen.Fluorophen
Chemical structure of gemazocine.GemazocineChemical structure of ibazocine.IbazocineChemical structure of ketazocine.KetazocineChemical structure of metazocine.MetazocineChemical structure of moxazocine .Moxazocine
Chemical structure of pentazocine.PentazocineChemical structure of phenazocine.PhenazocineChemical structure of quadazocine.QuadazocineChemical structure of tonazocine.Tonazocine
Chemical structure of volazocine.VolazocineChemical structure of zenazocine.Zenazocine

4-Phenylpiperidines

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Pethidine

Pethidines (meperidines)

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Structures
Pethidines (meperidines)
Chemical structure of 4-fluoropethidine.4-FluoropethidineChemical structure of 8-carboxamidocyclazocine.8-CarboxamidocyclazocineGeneral structure of allylnorpethidine.AllylnorpethidineChemical structure of anileridine.AnileridineChemical structure of benzethidine.Benzethidine
Chemical structure of carperidine.CarperidineChemical structure of difenoxin.DifenoxinChemical structure of diphenoxylate.DiphenoxylateChemical structure of etoxeridine.EtoxeridineChemical structure of furethidine.Furethidine
Chemical structure of hydroxypethidine.HydroxypethidineChemical structure of morpheridine.MorpheridineChemical structure of meperidine-N-oxide.Meperidine-N-oxideChemical structure of oxpheneridine.OxpheneridineChemical structure of pethidine.Pethidine
Chemical structure of pethidine intermediate A.Pethidine intermediate AChemical structure of pethidine intermediate B.Pethidine intermediate BChemical structure of pethidine intermediate C.Pethidine intermediate CChemical structure of pheneridine.PheneridineChemical structure of phenoperidine.Phenoperidine
Chemical structure of piminodine.PiminodineChemical structure of properidine.ProperidineChemical structure of sameridine.Sameridine

Prodines

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Structures
Prodines
Chemical structure of allylprodine.AllylprodineChemical structure of meprodine.(α/β)-MeprodineGeneral structure of desmethylprodine.Desmethylprodine (MPPP)Chemical structure of PEPAP.PEPAPChemical structure of drodine.Prodine
Chemical structure of prosidol.ProsidolChemical structure of prosidol.Prosidol

Ketobemidones

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Structures
Ketobemidones
Chemical structure of acetoxyketobemidone.AcetoxyketobemidoneChemical structure of droxypropine.DroxypropineGeneral structure of ketobemidone.KetobemidoneChemical structure of methylketobemidone.MethylketobemidoneChemical structure of propylketobemidone.Propylketobemidone

Others

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Structures
Other phenylpiperidines
Chemical structure of alvimopan.AlvimopanChemical structure of loperamide.LoperamideChemical structure of LS-115509.LS-115509General structure of picenadol.Picenadol

Open chain opioids

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Methadone

Amidones

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Structures
Amidones
Chemical structure of dextromethadone.

Dextromethadone

Chemical structure of dipipanone.

Dipipanone

General structure of isomethadone.

Isomethadone

Chemical structure of levoisomethadone.Levoisomethadone
Chemical structure of noracetylmethadol.NoracetylmethadolChemical structure of levomethadone.LevomethadoneChemical structure of methadone.MethadoneChemical structure of methadone intermediate.Methadone intermediate
Chemical structure of normethadone.NormethadoneChemical structure of norpipanone.NorpipanoneChemical structure of phenadoxone.PhenadoxoneChemical structure of pipidone.Pipidone

Methadols

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Structures
Other open chain opioids
Chemical structure of alphaacetylmethadol.

Alphaacetylmethadol

Chemical structure of fimepheptanol.

Dimepheptanol

General structure of levacetylmethadol.

Levacetylmethadol

Chemical structure of noracetylmethadol.

Noracetylmethadol

Moramides

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Structures
Other open chain opioids
Chemical structure of Desmethylmoramide.

Desmethylmoramide

Chemical structure of Dextromoramide.

Dextromoramide

General structure of Levomoramide.

Levomoramide

General structure of Moramide intermediate.

Moramide intermediate

General structure of Racemoramide.

Racemoramide

Thiambutenes

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Structures
Thiambutenes
Chemical structure of diethylthiambutene.

Diethylthiambutene

Chemical structure of dimethylthiambutene.

Dimethylthiambutene

General structure of ethylmethylthiambutene.

Ethylmethylthiambutene

General structure of piperidylthiambutene.

Piperidylthiambutene

General structure of thiambutene.

Thiambutene

General structure of tipepidine.

Tipepidine

Phenalkoxams

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Structures
Phenalkoxams
Chemical structure of dextropropoxyphene.

Dextropropoxyphene
(propoxyphene)

Chemical structure of dimenoxadol.

Dimenoxadol

General structure of dioxaphetyl butyrate.

Dioxaphetyl butyrate

General structure of levopropoxyphene.

Levopropoxyphene

General structure of norpropoxyphene.

Norpropoxyphene

Ampromides

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Structures
Ampromides
Chemical structure of diampromide.

Diampromide

Chemical structure of phenampromide.

Phenampromide

General structure of propiram.

Propiram

Others

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Structures
Other open chain opioids
Chemical structure of embutramide.

Embutramide

Chemical structure of IC-26.

IC-26

Chemical structure of isoaminile.

Isoaminile

General structure of lefetamine.

Lefetamine

Chemical structure of R-4066.

R-4066

Anilidopiperidines

[edit]
Fentanyl
Structures
Anilidopiperidines
Chemical structure of 3-allylfentanyl.3-AllylfentanylChemical structure of 3-methylfentanyl.3-MethylfentanylChemical structure of 3-methylthiofentanyl.3-MethylthiofentanylChemical structure of 4-phenylfentanyl .4-PhenylfentanylChemical structure of alfentanil.Alfentanil
Chemical structure of alphamethylacetylfentanyl.AlphamethylacetylfentanylChemical structure of alphamethylfentanyl.AlphamethylfentanylChemical structure of alphamethylthiofentanyl.Alpha-methylthiofentanylChemical structure of benzylfentanyl.BenzylfentanylChemical structure of betahydroxyfentanyl.Betahydroxyfentanyl
Chemical structure of betahydroxythiofentanyl.BetahydroxythiofentanylChemical structure of betamethylfentanyl.BetamethylfentanylChemical structure of brifentanil.BrifentanilChemical structure of carfentanil.CarfentanilChemical structure of fentanyl.Fentanyl
Chemical structure of lofentanil.LofentanilChemical structure of mirfentanil.MirfentanilChemical structure of ocfentanil.OcfentanilChemical structure of ohmefentanyl.OhmefentanylChemical structure of parafluorofentanyl.Parafluorofentanyl
Chemical structure of phenaridine.PhenaridineChemical structure of remifentanil.RemifentanilChemical structure of sufentanil.SufentanilChemical structure of thenylfentanyl.ThenylfentanylChemical structure of thiofentanyl.Thiofentanyl
Chemical structure of trefentanil.Trefentanil

Oripavine derivatives

[edit]
Thienorphine
Structures
Oripavine derivatives
Chemical structure of 7-PET.7-PETChemical structure of acetorphine.AcetorphineChemical structure of alletorphine.AlletorphineChemical structure of BU-48.BU-48Chemical structure of buprenorphine.Buprenorphine
Chemical structure of cyprenorphine.CyprenorphineChemical structure of dihydroetorphine.DihydroetorphineChemical structure of etorphine.EtorphineChemical structure of homprenorphine.HomprenorphineChemical structure of 18,19-dehydrobuprenorphine.18,19-Dehydrobuprenorphine
Chemical structure of N-cyclopropylmethylnoretorphine.N-cyclopropylmethylnoretorphineChemical structure of nepenthone.NepenthoneChemical structure of norbuprenorphine.NorbuprenorphineChemical structure of thevinone.ThevinoneChemical structure of thienorphine.Thienorphine

Phenazepanes

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Structures
Phenazepanes
Chemical structure of ethoheptazine.

Ethoheptazine

Chemical structure of meptazinol.

Meptazinol

Chemical structure of metheptazine.

Metheptazine

Chemical structure of metethoheptazine.

Metethoheptazine

Chemical structure of proheptazine.

Proheptazine

Pirinitramides

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Structures
Pirinitramides
Chemical structure of bezitramide.

Bezitramide

Chemical structure of piritramide.

Piritramide

Benzimidazoles

[edit]
Structures
Benzimidazoles
Chemical structure of clonitazene.

Clonitazene

Chemical structure of etonitazene.

Etonitazene

General structure of isotonitazene.

Isotonitazene

Chemical structure of metonitazene.

Metonitazene

General structure of nitazene.

Nitazene: R =hydrogen

Indoles

[edit]
Structures
Indoles
Chemical structure of 18-methoxycoronaridine.

18-Methoxycoronaridine

Chemical structure of 7-acetoxymitragynine.

7-Acetoxymitragynine

General structure of 7-hydroxymitragynine.

7-Hydroxymitragynine

General structure of akuammidine.

Akuammidine

General structure of akuammine.

Akuammine

General structure of eseroline.

Eseroline

General structure of hodgkinsine.

Hodgkinsine

General structure of mitragynine.

Mitragynine

General structure of pericine.

Pericine

General structure of pseudoakuammigine.

Pseudoakuammigine

Beta-Amino Ketones

[edit]
Structures
Indoles
Chemical structure of beta-amine ketone 'compound 29'

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines

[edit]
Structures
Diphenylmethylpiperazines
Chemical structure of BW373U86.

BW373U86

Chemical structure of DPI-221.

DPI-221

Chemical structure of DPI-287.

DPI-287

Chemical structure of DPI-3290.

DPI-3290

Chemical structure of SNC-80.

SNC-80

Opioid peptides

[edit]
β-neoendorphin

Dynorphins

[edit]
Structures
Dynorphins
Chemical structure of dermenkephalin.Big dynorphinChemical structure of dynorphin A.Dynorphin AChemical structure of dynorphin B.Dynorphin B

Endomorphins

[edit]

Endorphins

[edit]
Structures
Dynorphins
Chemical structure of alpha-endorphin.
Alpha-endorphin		Chemical structure of beta-endorphin.
Beta-endorphin		Chemical structure of gamma-endorphin.
Gamma-endorphin		Chemical structure of α-neo-endorphin.
α-neoendorphin		Chemical structure of β-neo-endorphin.
β-neoendorphin

Enkephalins

[edit]
Structures
Enkephalins
Chemical structure of DADLE.DADLEChemical structure of DAMGO.DAMGOChemical structure of deltorphin.DeltorphinChemical structure of Met-enkephalin.Met-enkephalinChemical structure of Leu-enkephalin.Leu-enkephalin

Propeptides

[edit]

Others / unknown

[edit]
Structures
Other or unknown opioid peptides
Chemical structure of adrenorphin.AdrenorphinChemical structure of amidorphin.AmidorphinChemical structure of casomorphin.CasomorphinChemical structure of DALDA.DALDAChemical structure of deltorphin.Deltorphin
Chemical structure of dermorphin.DermorphinChemical structure of DPDPE.DPDPEChemical structure of Endomorphin-1.Endomorphin-1
Chemical structure of Endomorphin-2.Endomorphin-2		Chemical structure of gliadorphin.GliadorphinChemical structure of morphiceptin.Morphiceptin
Chemical structure of nociceptin.NociceptinChemical structure of octreotide.OctreotideChemical structure of opiorphin.OpiorphinChemical structure of rubiscolin.RubiscolinChemical structure of TRIMU 5.TRIMU 5

Others

[edit]

Opioid antagonists and inverse agonists

[edit]

Biased ligands

[edit]

Receptor heteromer targeting ligands

[edit]

Uncategorized opioids

[edit]
Structures
Uncategorized opioids
Chemical structure of alimadol.

Alimadol

Chemical structure of anilopam.

Anilopam

Chemical structure of asimadoline.

Asimadoline

Chemical structure of FE 200665.

FE 200665

Chemical structure of fedotozine.

Fedotozine

Chemical structure of MCOPPB.

MCOPPB

Chemical structure of nalfurafine.

Nalfurafine

Chemical structure of nalodeine.NalodeineChemical structure of nalorphine.

Nalorphine

Chemical structure of nalorphine dinicotinate.

Nalorphine dinicotinate

Chemical structure of SoRI-9409.

SoRI-9409

Combination drug formulations containing opioids

[edit]

See also

[edit]

References

[edit]
  1. ^ChemIndex CAS Registry Number 3371-56-0
  2. ^ChemIndex CAS Registry Number 509-56-8
  3. ^ChemIndex CAS Registry Number 63715-94-6
  4. ^NCBI PubChem SID 750205
  5. ^chembase[permanent dead link] cbid_346222
  6. ^Gomes I, Fujita W, Gupta A, Saldanha SA, Saldanha AS, Negri A, Pinello CE, Eberhart C, Roberts E, Filizola M, Hodder P, Devi LA (2013)."Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity".Proc. Natl. Acad. Sci. U.S.A.110 (29):12072–7.Bibcode:2013PNAS..11012072G.doi:10.1073/pnas.1222044110.PMC 3718106.PMID 23818586.
  7. ^Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS (2011)."N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers".Proc. Natl. Acad. Sci. U.S.A.108 (12):5098–103.Bibcode:2011PNAS..108.5098Y.doi:10.1073/pnas.1016277108.PMC 3064379.PMID 21385944.

External links

[edit]
  • Carbonate derivatives of 14β-hydroxycodeine"viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ringC modification in morphinane (sic) alkaloids, were synthesized for the first time."Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740
μ-opioid
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Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
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(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
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