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List of allergens

From Wikipedia, the free encyclopedia

This is a list ofallergies, which includes theallergen, potential reactions, and a brief description of the cause where applicable.

Allergens

[edit]

Food

[edit]
Main article:Food allergy
NamePotential reaction(s)Remarks
Balsam of PeruRedness, swelling, itching,allergiccontact dermatitis reactions,stomatitis (inflammation and soreness of the mouth or tongue),cheilitis (inflammation, rash, or painful erosion of the lips,oropharyngealmucosa, or angles of their mouth),pruritus,hand eczema, generalized or resistantplantardermatitis,rhinitis,conjunctivitis, and blisters.Present in many foods, such as coffee, flavored tea, wine, beer, gin, liqueurs, apéritifs (e.g. vermouth, bitters), soft drinks including cola, juice, citrus, citrus fruit peel, marmalade, tomatoes and tomato-containing products, Mexican and Italian foods with red sauces, ketchup, spices (e.g.cloves,Jamaica pepper (allspice),cinnamon,nutmeg,paprika,curry,anise, andginger), chili sauce, barbecue sauce,chutney, pickles, pickled vegetables, chocolate, vanilla, baked goods and pastries, pudding, ice cream, chewing gum, and candy.
Buckwheat[1]Asthma, rhinitis, pruritus, gastrointestinal disturbances, urticaria, angioedema, shock, anaphylaxis[2]Allergenicity is highest in Japan and Korea.[3] It is estimated that buckwheat causes 5% of all immediate-type allergic reaction cases (from food) in Japan.[4] Hazard extends to inhalation of milled flour particles (aeroallergen). Irrespective of the nomenclature, it is not awheaten cereal; the name refers to its viability as apseudocereal. Relating or conflating buckwheat allergy with wheat allergy orTriticeae hypersensitivities should be avoided.[5]
CeleryAbdominal pain,nausea,vomiting, oral allergy syndrome, urticaria, neck or facial swelling, severe asthma symptoms, exercise induced anaphylaxis, potentially fatal anaphylactic shocks[6]Higher risk of provoking life-threatening reactions compared to most other food allergies. Celery seeds andceleriac are more allergenic than celery stalks.[7][8] Some individuals become cross-sensitized to other spices and herbs in theparsley family. Prevalence is high among adults inCentral Europe. It is estimated that two-fifths of all Swiss food-allergy patients react to celery tubers and nearly a third of severe food allergy reactions in France may be due to celery.[9]
EggAnaphylaxis, swelling, sometimes flatulence and vomitingAn allergic individual may not have any reaction to consuming food only prepared withegg yolk and notegg white, or vice versa.[10] Due to high protein content, egg white allergy is more common than the reverse.[11] The majority of children with this allergy become tolerant by adulthood.[12]
FishRespiratory reactions, Anaphylaxis, oral allergy syndrome, sometimes vomitingOne of three allergies toseafood, not to be conflated with allergies to crustaceans and mollusks.[13] People with fish allergies have a 50% likelihood of being cross reactive with another fish species,[14] but some individuals are only allergic to one species, such as; tilapia[15] salmon,[13] or cod. A proper diagnosis is considered complicated due to these cross reactivity between fish species and other seafood allergies.[16] Hazard extends to exposure to cooking vapors or handling.[17]
FruitMild itching, rash, generalized urticaria, oral allergy syndrome, abdominal pain, vomiting, anaphylaxisMango,strawberries,banana,[18]avocado, andkiwi are common problems.[19] Severe allergies totomatoes have also been reported.[20][21]Stone fruits are highly cross-reactive with one another, as are therosaceae fruits[22][10] Reaction tohot peppers, a kind of botanical berry, is another specific type of fruit allergy.
GarlicDermatitis, rhinitis, asthma, urticaria, asymmetrical pattern of fissure, thickening/shedding of the outer skin layers,[23] rarelyanaphylaxisVery few garlic allergens have been reported, and garlic allergy has been rarely studied. Some garlic-allergic individuals may cross-react with leek, shallot and onion. Garlic that has been heated/cooked is less allergenic than raw garlic.[24][25]
OatsDermatitis, respiratory problems, anaphylaxisRisk extends to respiratory inhalation. Oat is not a triticeae cereal but it is possible for individuals withgluten-related disorders to be misdiagnosed as having a hypersensitivity to pure oat because cross-contamination is very common in the western world.
MaizeHives, pallor, confusion, dizziness, stomach pain, swelling, vomiting, indigestion, diarrhea, cough, tightness in throat, wheezing, shortness of breath, anaphylaxisOften a difficult allergy to manage due to the various food products which contain various forms of corn.
Milk[26]Skin rash, hives, vomiting, diarrhea, constipation, stomach pain, flatulence, colitis, nasal congestion, dermatitis, blisters, migraine, anaphylaxisNot to be confused with lactose intolerance.[27] Allergy to cow's milk is the most common food allergy in infants and young children[11] but most outgrow the allergy in early childhood. Introducing baked cow's milk to allergic patients is associated with accelerated resolution of milk allergy.[28] Some evidence suggests goat's milk has less allergenic potential than cow's milk[29] and reduced risk of allergy development if infants are weaned with goat's milk.[30] Due to adult-onset sensitization it is estimated to be the second most common food allergy in American adults.[31]
MustardEczema, Rash, Hives, Facial swelling, Other skin reactions, Oral allergy syndrome, Conjunctivitis, Wheezing, Abdominal pain, Diarrhea, Nausea, Vomiting, Acid Reflux, Dizziness, Asthma, Chest pain, Respiratory problems, AnaphylaxisMustard allergy onset is usually in infancy or toddlerhood;[32] it is seemingly very rare but true prevalence can not be established due to several tests producing high rates of false positives.[33] Due to a gradual increase in prevalence[34] and the severity of known reactions it became recognized as the 11th priority allergen by Canada in 2009,[35] and a top 14 priority allergen by the European Union in 2014.[36][37]
Peanut[38]Anaphylaxis and swelling, sometimes vomitingIncludes some cold-pressedpeanut oils. Distinct from tree nut allergy, as peanuts arelegumes. Reactions are often severe or fatal.
Poultry Meat[39]Hives,swelling of, or under the dermis, nausea, vomiting, diarrhea, severeoral allergy syndrome, shortness of breath, rarelyanaphylactic shockVery rare allergies tochicken,turkey,squab, and sometimes more mildly to other avian meats. Not to be confused with secondary reactions of bird-egg syndrome. The genuine allergy has no causal relationship with egg allergy, nor is there any close association with red meat allergy. Prevalence still unknown as of 2016.[40]
Red Meat[41]Hives, swelling, dermatitis, stomach pain, nausea, vomiting, dizziness, fainting, shortness of breath,[42] anaphylaxisAllergies to the sugar carbohydrate found inbeef,venison,lamb, andpork calledalpha-gal. It is brought on by tick bites.[43] Allergic reaction to pork is an exception, as it may also be caused bypork-cat syndrome instead ofalpha-gal allergy.
RiceSneezing, runny nose, itching, stomachache, eczema.People with a rice allergy can be affected by eating rice or breathing in rice steam.
SesamePossible respiratory, skin, and gastrointestinal reactions which can trigger serious systemic anaphylactic responses.[44][45]By law, foods containing sesame must be labeled so in European Union, Canada, Australia, and New Zealand.[44] Increasing prevalence has led to it being deemed the ninth most common food allergen in the United States in 2019. Highest prevalence by age was among 18-29 year olds and an estimated 80% of all sesame-allergic patients had a comorbid food allergy.[46] In 2018, the USFDA issued a request for information for the consideration of labeling for sesame to help protect people who have sesame allergies.[47] A decision was reached in November 2020 that food manufacturers voluntarily declare that when powdered sesame seeds are used as a previously unspecified spice or flavor, the label be changed to "spice (sesame)" or "flavor (sesame)".[48] Via congressional act, it was declared that food manufacturers must acknowledge sesame as a priority food allergen by the 2023 deadline.[49]
ShellfishRespiratory symptoms, Anaphylaxis, oral allergy syndrome, gastrointestinal symptoms, rhinitis, conjunctivitisShellfish allergies are highly cross reactive, but its prevalence is much higher than that of fish allergy. Shellfish allergy is the leading cause of food allergy in U.S adults.[31] As of 2018 six allergens have been identified to prawn alone; along with crab, it is the major culprit of seafood anaphylaxis.[13] In reference to it as one of the "Big 8"[50] or "major 14" allergens it is sometimes specified as a "crustacean shellfish" allergy, or more simply, a "crustacean allergy".[51][52] Sometimes it is conflated with an allergy to molluscan shellfish but complete tolerance to one but not the other is not uncommon. Most usually, a mono-sensitive individual will experience a crustacean allergy alone with tolerance to mollusks, rather than vice versa.[13] The symptoms of an allergic reaction to molluscan shellfish should not be confused with the effects ofshellfish poisoning which are a medical reactions that manifest after eating contaminated mollusks from certain areas of the world and lasts for several hours or days after onset.[53]
SoyAnaphylaxis, asthma exacerbation, rhinitis, allergic conjunctivitis, hives, atopic dermatitis, swelling of, or under the dermis, diarrhea, nausea, vomitingOverall is lower in prevalence than both peanut allergy and cow's milk allergy. However, due to similar protein structures soya is a common cross-reactive allergen in both peanut-allergic individuals and milk-allergic individuals; especially infants.[54]
SulfitesHives, rash, redness of skin, headache (particular frontal), burning behind eyes, asthma-like breathing difficulties, anaphylaxisSulfites (also spelled "sulphites") are used as a preserving agents in many different foods, such as raisins, dried peaches, various otherdried fruit, canned or frozen fruits and vegetables, wines, vinegars and processed meats. Allergy appears to be very rare in the general population but it is still often considered to be one of the top 10 food allergies.[55] It is debated whether reaction to sulfites is a true allergy.[56]
TartrazineSkin irritation, hives, rashA synthetic food dye used in processed foods likeconfections,soft drinks,flavoring syrups,condiments andconvenience foods in order to create a potent yellow or bright green coloring. Prevalence of allergenicity is unclear but it is the most likelyazo dye to cause hypersensitivity and reactions may occur from ingestion or skin contact. It is possible for some individuals to become desensitized. There is no strong evidence suggesting that tartrazine can cause hypersensitivity or intolerance in non-allergic individuals.
Tree nut[57]Anaphylaxis, swelling, rash, hives, sometimes vomitingHazard extends to exposure to cooking vapors, or handling. Distinct from peanut allergy, as peanuts arelegumes.
Wheat[58]Eczema (atopic dermatitis),Hives,asthma, "baker's asthma",hay fever, oral allergy syndrome, angioedema, abdominal cramps,Celiac disease, diarrhea, temporary (3 or 4 day) mental incompetence, anemia,nausea,vomiting and exercise induced anaphylaxis[59]Risk extends to wheat hybrids liketriticale.[55] True wheat allergies are very rare; it is estimated to effect 0.1%-2.2% of individuals depending on region.[60] The allergy does not commonly persist into adolescence. Gluten-free foods are safer for wheat allergic patients but they still may theoretically contain wheat's other allergenic proteins.[61] Wheat allergy symptoms should not be confused withceliac disease, gluten ataxia ornon-celiac gluten sensitivity (NCGS). While wheat allergies are "true" allergies, celiac disease and gluten ataxia are an autoimmune diseases.[62] NCGS is more similar tofood intolerances but as of 2021 its pathogenesis is still not well understood.

Medical

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Main article:Drug allergy
NamePossible reaction(s)Remarks
Balsam of PeruRedness, swelling, itching,allergiccontact dermatitis reactions,stomatitis (inflammation and soreness of the mouth or tongue),cheilitis (inflammation, rash, or painful erosion of the lips,oropharyngealmucosa, or angles of their mouth),pruritus,hand eczema, generalized or resistantplantardermatitis,rhinitis,conjunctivitis, and blisters.Present in many drugs, such ashemorrhoid suppositories and ointment (e.g.Anusol), cough medicine/suppressant and lozenges,diaper rash ointments, oral and lip ointments,tincture of benzoin, wound spray (it has been reported to inhibitMycobacterium tuberculosis as well as the common ulcer-causing bacteriaH. pylori in test-tube studies),calamine lotion, surgical dressings,dental cement,eugenol used by dentists, someperiodontal impression materials, and in the treatment ofdry socket in dentistry.
TetracyclineMany, including: severe headache, dizziness, blurred vision, fever, chills, body aches, flu symptoms, severe blistering, peeling, dark colored urine[63][64]
DilantinMany, including: swollen glands, easy bruising or bleeding, fever, sore throat[65][66][67]
Tegretol (carbamazepine)Shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue etc., hives[68][69][70]
PenicillinDiarrhea,hypersensitivity,nausea, rash,neurotoxicity,urticaria
CephalosporinsMaculopapular or morbilliform skin eruption, and less commonly urticaria, eosinophilia, serum-sickness–like reactions, and anaphylaxis.[71]
SulfonamidesUrinary tract disorders, haemopoietic disorders, porphyria and hypersensitivity reactions,Stevens–Johnson syndrometoxic epidermal necrolysis
Non-steroidal anti-inflammatories (cromolyn sodium, nedocromil sodium, etc.)Many, including: swollen eyes, lips, or tongue, difficulty swallowing, shortness of breath, rapid heart rate[72]
Intravenous contrast dyeAnaphylactoid reactions and contrast-induced nephropathy
Local anestheticsUrticaria and rash, dyspnea, wheezing, flushing, cyanosis, tachycardia[73]

Environmental

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Main article:Allergy § Other environmental factors
NamePossible reaction(s)Remarks
Balsam of PeruRedness, swelling, itching,allergiccontact dermatitis reactions,stomatitis (inflammation and soreness of the mouth or tongue),cheilitis (inflammation, rash, or painful erosion of the lips,oropharyngealmucosa, or angles of their mouth),pruritus,hand eczema, generalized or resistantplantardermatitis,rhinitis,conjunctivitis, and blisters.A number of national and international surveys have identified Balsam of Peru as being in the "top five" allergens causing patch test reactions in people referred to dermatology clinics.[74][75]
PollenSneezing, body ache, headache (in rare cases, extremely painfulcluster headaches may occur due to allergicsinusitis; these may leave a temporary time period of 1 and a half to 2 days with eye sensitivity), allergicconjunctivitis (includes watery, red, swelled, itchy, and irritating eyes),runny nose, irritation of the nose, nasal congestion, minor fatigue, chest pain and discomfort, coughing, sore throat, facial discomfort (feeling of stuffed face) due to allergic sinusitis, possibleasthma attack, wheezing
CatSneezing, itchy swollen eyes, rash, congestion, wheezing
DogRash, sneezing, congestion, wheezing, vomiting from coughing, Sometimes itchy welts.Caused bydander,saliva or urine of dogs, or by dust, pollen or other allergens that have been carried on the fur.[76] Allergy to dogs is present in as much as 10 percent of the population.[76]
Insect stingHives, wheezing, possible anaphylaxisPossible frombee orwasp stings, or bites frommosquitoes or flies likeLeptoconops torrens.
MoldSneeze, coughing, itchy, discharge from the nose, respiratory irritation, congested feeling,[77] joint aches, headaches, fatigue[78]
PerfumeItchy eyes, runny nose, sore throat, headaches, muscle/joint pain, asthma attack, wheezing, chest pain, blisters
CosmeticsContact dermatitis,[79] irritant contact dermatitis, inflammation, redness,[80] conjunctivitis,[81] sneezing
SemenBurning, pain and swelling, possibly for days, swelling or blisters, vaginal redness,[82] fever, runny nose, extreme fatigue[83][84][85][86][87]In a case study in Switzerland, a woman who was allergic to Balsam of Peru was allergic to her boyfriend's semen following intercourse, after he drank large amounts of Coca-Cola.[88]
LatexContact dermatitis,hypersensitivity
Water (see note)Epidermal itching, swelling of the oral cavity after drinking water, anaphylaxis (in severe cases)[89][90][91][92][93]Strictlyaquagenic pruritus oraquagenic urticaria, but cold water may also causecold urticaria
Cold stimuliHives, itchingKnown ascold urticaria
House dust mite[94]AsthmaHome allergen reduction may be recommended
Nickel (nickel sulfate hexahydrate)Allergic contact dermatitis,dyshidrotic eczema[95][96]
Gold (gold sodium thiosulfate)Allergic contact dermatitis
ChromiumAllergic contact dermatitis
Cobalt chlorideAllergic contact dermatitis
FormaldehydeAllergic contact dermatitis
Photographic developersAllergic contact dermatitis
FungicideAllergic contact dermatitis, fever, anaphylaxis

Contact

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Many substances can cause an allergic reaction when in contact with the humanintegumentary system.

Contact allergens
AllergenSourceCross reacts withClinical presentation
Dimethylaminopropylamine (DMAPA)Found withincocamidopropyl betaine in liquid soaps and shampoosEyelid dermatitis
Latex[nb 1]Avocado
Banana
Chestnut
Kiwi
Passion fruit
Peach
Mango
Pineapple
Fig
Cantaloupe
Apple
Papaya
Ethylene-ripened fruits
Paraphenylenediamine (PPD)Black hair dye
Color developer
Scuba gear
Henna[nb 2]
Para-aminobenzoic acid (PABA)
Azo dyes
Sulfonamides
Sulfonylureas
Thiazides
Ester anesthetics
Glyceryl monothioglycolatePermanent hair waving solutions
Tosylamide/formaldehyde resin (TSFR)Nail polishEyelid dermatitis
p-tert-butylphenol-formaldehyde resin (PTBP-FR)Adhesive in craft glues and commercial leather and rubber productsFoot dermatitis[97][98]: 793 
  1. ^Risk factors for reaction to latex includespina bifida, family history of allergy to latex, or a personal history of allergies,asthma, oreczema
  2. ^Paraphenylenediamine may be added to henna but is not found in pure henna.

See also

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References

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Further reading

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Other conditions
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Temperature
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Maltreatment
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Adverse effect
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Ungrouped
skin conditions
resulting from
physical factors
Type I/allergy/atopy
(IgE)
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Foreign
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(Immune complex)
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(T cells)
Foreign
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General
Food industry
Adulterants,food contaminants
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Intestinal parasites,parasitic disease
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